New drug combo targets tough lung cancer in small early trial

NCT ID NCT04227028

Ongoing Disease control Sponsor: City of Hope Medical Center Source: ClinicalTrials.gov ↗

First seen Oct 31, 2025 · Last updated Apr 30, 2026 · Updated 22 times

Summary

This early-phase study tests a combination of two drugs, brigatinib and bevacizumab, in about 5 people with a specific type of advanced lung cancer (ALK-positive) that has continued to grow despite prior treatment. The main goals are to find the best dose and check for side effects. This is not a cure, but aims to control the disease.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Locations

City of Hope Medical Center

Duarte, California, 91010, United States
Northwestern University

Chicago, Illinois, 60611, United States
Penn State Cancer Institute

Hershey, Pennsylvania, 17033, United States
Rush University Medical Center

Chicago, Illinois, 60612, United States
University of Colorado Cancer Center

Aurora, Colorado, 80045, United States
University of Wisconsin Hospital and Clinics

Madison, Wisconsin, 53792, United States

Conditions

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