Experimental drug combo aims to outsmart resistant lung cancer
NCT ID NCT02503722
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This early-phase trial tests a combination of two targeted drugs, sapanisertib and osimertinib, in people with advanced EGFR-mutant non-small cell lung cancer that has stopped responding to osimertinib alone. The main goals are to find the safest dose and understand side effects. About 36 participants will take both pills by mouth to see if the combination can block cancer growth in a new way.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
sapanisertib and osimertinib
What this could lead to
If this works, it could point toward a new treatment option for people with a specific type of lung cancer that has stopped responding to current targeted therapy.
What could go wrong
This is a very early (Phase 1) trial with only 36 participants, so the main goal is safety and dosing, not yet proof of effectiveness. The combination may cause significant side effects and may not work for everyone.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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BCCA-Vancouver Cancer Centre
Vancouver, British Columbia, V5Z 4E6, Canada
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Moffitt Cancer Center
Tampa, Florida, 33612, United States
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Smilow Cancer Center/Yale-New Haven Hospital
New Haven, Connecticut, 06510, United States
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University Health Network-Princess Margaret Hospital
Toronto, Ontario, M5G 2M9, Canada
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Yale University
New Haven, Connecticut, 06520, United States