Experimental combo targets lung cancer brain metastases in early trial
NCT ID NCT02589522
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This early-phase trial is testing the safety and best dose of a drug called berzosertib when given together with whole brain radiation therapy. The study includes 15 people with lung cancer that has spread to the brain. The goal is to find out if this combination is safe enough to study further.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- berzosertib (M6620, VX-970) plus whole brain radiation therapy
- What this could lead to
- If this works, it could point toward a more effective treatment for lung cancer that has spread to the brain, potentially improving control of the disease.
- What could go wrong
- This is a very early, small phase 1 trial with only 15 participants, focused on safety and dosing. It is not designed to prove the treatment works, and there may be significant side effects from the combination.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Case Western Reserve University
Cleveland, Ohio, 44106, United States
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City of Hope Comprehensive Cancer Center
Duarte, California, 91010, United States
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Johns Hopkins University/Sidney Kimmel Cancer Center
Baltimore, Maryland, 21287, United States
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Mayo Clinic in Florida
Jacksonville, Florida, 32224-9980, United States
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Mayo Clinic in Rochester
Rochester, Minnesota, 55905, United States
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University of California Davis Comprehensive Cancer Center
Sacramento, California, 95817, United States
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University of Kentucky/Markey Cancer Center
Lexington, Kentucky, 40536, United States
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University of Maryland/Greenebaum Cancer Center
Baltimore, Maryland, 21201, United States
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Washington University School of Medicine
St Louis, Missouri, 63110, United States
More trials for these conditions
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