New scan could predict which brain tumors will shrink
NCT ID NCT05376878
First seen Jun 27, 2026 · Last updated Jul 01, 2026 · Updated 1 time
Summary
This pilot study tests a special PET/MRI scan that uses a radioactive tracer to find HER2+ breast cancer that has spread to the brain. The scan aims to show whether the cancer cells take up the tracer, which might predict if they will respond to the standard drug trastuzumab deruxtecan. Ten women with HER2+ breast cancer and brain metastases will be scanned before starting treatment. The goal is to see if the scan can help guide therapy.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
64Cu-DOTA-Trastuzumab (a radioactive tracer for imaging)
What this could lead to
If successful, this scan could help doctors see which brain metastases will respond to trastuzumab deruxtecan, guiding personalized treatment.
What could go wrong
This is a very small pilot study (10 people) focused on imaging, not treatment. The scan may not reliably predict outcomes, and results may not apply to all patients.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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City of Hope Medical Center
RECRUITINGDuarte, California, 91010, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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