METASTATIC BREAST CARCINOMA

This study is testing a precise, high-dose radiation treatment for people with estrogen receptor-positive (ER+) breast cancer that has spread to a few new spots in the body. The goal is to see if zapping those few spots with radiation allows patients to safely continue their curr…

This early-phase study aims to find a safe and tolerable dose of a new drug combination for people with advanced breast cancer and other solid tumors that have a protein called HER2. The trial will test pidnarulex, which aims to stop tumor cell growth, together with an existing t…

This early-stage trial is testing the safety of combining a wearable device that uses electric fields to disrupt cancer cells with different drug combinations. It is for adults with advanced cancers in the abdomen or chest that have spread and who have run out of standard treatme…

This study is testing if using highly focused radiation on a single tumor that has started growing again can help people with metastatic breast cancer stay on their current effective drug treatments longer. Participants will receive this targeted radiation while continuing their …

This small, early-stage study is testing whether a portable device that creates electric fields is safe and practical for people with breast or lung cancer that has spread to the lining of the spinal cord. Participants wear the device on their back for most of the day, aiming to …

This study compares two different hormone-blocking treatments (leuprolide and goserelin) for premenopausal women with breast cancer. Both drugs work by reducing estrogen production, which can help slow or stop cancer growth. Researchers will measure how well each treatment lowers…

This study is testing two new drug combinations for people with advanced, BRCA-positive breast cancer that has spread and has stopped responding to a standard type of targeted therapy (PARP inhibitors). The trial will see if adding a second drug to the standard one can shrink tum…

This study aims to find the best radiation method for treating cancer that has spread to the brain. It compares giving one large radiation dose versus spreading the same total radiation over three smaller treatments. Researchers want to see which approach better controls the brai…

This early-stage study aims to find the safest dose of two oral drugs—ZEN003694 and abemaciclib—when given together to patients with advanced cancers that have spread or cannot be removed by surgery. The trial will enroll about 45 adults and teens (12+) with specific cancers, inc…

This study is testing a combination treatment for breast cancer that has spread to the liver. It pairs an immunotherapy drug (cemiplimab) that helps the immune system fight cancer with a targeted radiation treatment (Y90) delivered directly to liver tumors. The main goal is to se…

This study is testing whether the drug talazoparib can help control advanced cancers in patients whose tumors have specific mutations in genes that help repair DNA damage. It is enrolling 36 adults with various advanced solid tumors (like breast, ovarian, prostate, pancreatic, an…

This early-stage study is testing the safety and best dose of a new two-drug combination for people with advanced solid tumors that have a specific marker called HER2. The treatment pairs an existing targeted cancer drug with a new pill that aims to block cancer cells' ability to…

This study tests whether a patient's own immune cells, removed from their tumor and multiplied in a lab, can shrink tumors when given back alongside the drug pembrolizumab. It's for adults with advanced digestive tract, breast, ovarian, or other cancers that have spread and stopp…

This study is testing a specialized radiation technique for patients with breast or lung cancer that has spread to the fluid around the brain and spine. The goal is to see if precisely targeting the entire brain and spinal cord with radiation, while avoiding a key memory area, ca…

This study is for people with breast or non-small cell lung cancer that has spread to the fluid-filled space around the brain and spinal cord. It compares two types of radiation therapy to see which one helps patients live longer. One method targets only the specific areas causin…

This study is testing how well older adults tolerate a breast cancer drug called abemaciclib. It is for people aged 70 and older whose hormone-positive breast cancer has spread and worsened after previous treatments. The main goal is to understand the side effects and safety of t…

This study is testing a specialized radiation treatment for patients whose breast or lung cancer has spread to the fluid surrounding the brain and spinal cord. The treatment aims to target all areas where this type of cancer spread might occur. Researchers want to see if this app…

This study aims to compare two types of imaging scans to see which is better at finding and tracking metastatic lobular breast cancer. Researchers will test a new scan (FES PET/CT) against the standard scan (FDG PET/CT) in 30 adults with this specific cancer type. The goal is to …

This study is testing a new type of PET/MRI scan to see if it can help doctors better understand and predict how well a standard breast cancer treatment will work when the cancer has spread to the brain. Researchers will give the scan to 10 women with this specific type of advanc…

This study is testing a new type of PET scan to see if it can better show how well a patient's breast cancer is responding to certain targeted drug treatments. The scan uses a special tracer that lights up a specific protein in cancer cells. Researchers want to see if this new sc…

This study aims to learn more about the tiny blood vessels that feed solid tumors. Researchers will use a special microscope during a patient's standard cancer surgery to see these vessels in real time. The goal is to understand how tumor blood flow works and if it relates to how…

This study follows 700 patients with advanced breast cancer who are taking specific cancer drugs called CDK4/6 inhibitors. Researchers will collect blood and tissue samples to understand why some patients respond well to treatment while others develop resistance. The goal is to l…

This study aims to create a collection of blood and tissue samples from patients whose breast cancer has returned or spread. Researchers will use these samples to learn more about how the cancer changes and responds to treatments over time. The goal is to build a resource that he…

This study aims to learn from people living with advanced breast cancer and their caregivers about their experiences with care and support. Researchers will survey and interview 50 participants across four groups to understand what has been helpful, what has been difficult, and w…