New hope for seniors with breast cancer: drug combo trial targets tough cases

NCT ID NCT04305834

Recruiting now Disease control Sponsor: City of Hope Medical Center Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This phase 2 trial is testing the safety of abemaciclib (Verzenio) combined with hormone therapy in people aged 70 and older with hormone receptor-positive metastatic breast cancer that has worsened after prior treatment with a similar drug. The study will enroll 43 participants and track side effects, dose adjustments, and quality of life. It aims to find a tolerable option for older adults who have limited choices after standard treatments stop working.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: abemaciclib (Verzenio) plus endocrine therapy
What this could lead to: If it works, this could offer a tolerable treatment option for older adults with metastatic breast cancer who have already tried a similar drug.
What could go wrong: This is a small, early-phase trial focused on side effects, not on how well the drug works. The drug may cause serious side effects or not control the cancer.

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Conditions

The condition(s) this trial relates to.

breast cancer breast carcinoma breast neoplasm hormone receptor-positive breast cancer metastatic neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ANATOMIC STAGE IV BREAST CANCER AJCC V8 HORMONE RECEPTOR POSITIVE BREAST CARCINOMA METASTATIC BREAST CARCINOMA PROGNOSTIC STAGE IV BREAST CANCER AJCC V8

Contacts and locations

Locations

City of Hope Medical Center
RECRUITING

Duarte, California, 91010, United States
City of Hope South Pasadena
RECRUITING

South Pasadena, California, 91030, United States
City of Hope at Irvine Lennar
RECRUITING

Irvine, California, 92618, United States
City of Hope at Long Beach Elm
RECRUITING

Long Beach, California, 90813, United States
Dana Farber Cancer Institute
RECRUITING

Boston, Massachusetts, 02215, United States
Roswell Park Comprehensive Cancer Center
RECRUITING

Buffalo, New York, 14203, United States

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