New hope for seniors with breast cancer: drug combo trial targets tough cases
NCT ID NCT04305834
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This phase 2 trial is testing the safety of abemaciclib (Verzenio) combined with hormone therapy in people aged 70 and older with hormone receptor-positive metastatic breast cancer that has worsened after prior treatment with a similar drug. The study will enroll 43 participants and track side effects, dose adjustments, and quality of life. It aims to find a tolerable option for older adults who have limited choices after standard treatments stop working.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
abemaciclib (Verzenio) plus endocrine therapy
What this could lead to
If it works, this could offer a tolerable treatment option for older adults with metastatic breast cancer who have already tried a similar drug.
What could go wrong
This is a small, early-phase trial focused on side effects, not on how well the drug works. The drug may cause serious side effects or not control the cancer.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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City of Hope Medical Center
RECRUITINGDuarte, California, 91010, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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City of Hope South Pasadena
RECRUITINGSouth Pasadena, California, 91030, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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City of Hope at Irvine Lennar
RECRUITINGIrvine, California, 92618, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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City of Hope at Long Beach Elm
RECRUITINGLong Beach, California, 90813, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Dana Farber Cancer Institute
RECRUITINGBoston, Massachusetts, 02215, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Roswell Park Comprehensive Cancer Center
RECRUITINGBuffalo, New York, 14203, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••