ANATOMIC STAGE IV BREAST CANCER AJCC V8
Clinical trials for ANATOMIC STAGE IV BREAST CANCER AJCC V8 explained in plain language.
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Brain cancer trial halted early: can Memory-Sparing radiation help when tumors return?
Disease control TerminatedThis phase III trial compared two radiation strategies for cancer that had spread to the brain and returned in new spots after initial radiosurgery. One group received focused radiation only to the new tumors, while the other received whole brain radiation that avoided the memory…
Matched conditions: ANATOMIC STAGE IV BREAST CANCER AJCC V8
Phase: PHASE3 • Sponsor: NRG Oncology • Aim: Disease control
Last updated Jun 27, 2026 12:35 UTC
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Tailored cancer therapy put to the test
Disease control TerminatedThis study tested a precision medicine approach for people with advanced cancers like breast, ovarian, pancreatic, prostate, or sarcoma. Researchers used genetic and protein tests to track how the cancer changes and then a team of experts recommended personalized drugs. The goal …
Matched conditions: ANATOMIC STAGE IV BREAST CANCER AJCC V8
Phase: PHASE2 • Sponsor: OHSU Knight Cancer Institute • Aim: Disease control
Last updated Jun 27, 2026 12:25 UTC
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New drug combo targets brain metastases in advanced cancers
Disease control TerminatedThis study tested a combination of two drugs, bintrafusp alfa and pimasertib, in people whose cancer had spread to the brain. The goal was to find the safest dose and see if the treatment could slow or stop the cancer from growing. The trial was stopped early after enrolling only…
Matched conditions: ANATOMIC STAGE IV BREAST CANCER AJCC V8
Phase: PHASE1, PHASE2 • Sponsor: M.D. Anderson Cancer Center • Aim: Disease control
Last updated Jun 27, 2026 11:02 UTC
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Promising breast cancer combo trial shutters after just one patient
Disease control TerminatedThis phase 2 trial aimed to see if adding the targeted drug binimetinib to the standard hormone therapy fulvestrant could help people with a certain genetic change (NF1) in hormone receptor-positive breast cancer that has spread. Only one person enrolled before the study was term…
Matched conditions: ANATOMIC STAGE IV BREAST CANCER AJCC V8
Phase: PHASE2 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated Jun 27, 2026 09:09 UTC
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New cocktail of drugs tested for Hard-to-Treat breast cancer – but trial halted early
Disease control TerminatedThis phase II study tested several drug combinations for people with metastatic triple-negative breast cancer, a type that has spread and lacks common hormone targets. The drugs included olaparib (a PARP inhibitor) paired with either durvalumab (an immunotherapy), selumetinib, ca…
Matched conditions: ANATOMIC STAGE IV BREAST CANCER AJCC V8
Phase: PHASE2 • Sponsor: Gordon Mills, MD, PhD • Aim: Disease control
Last updated Jun 27, 2026 09:08 UTC
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Promising combo for inflammatory breast cancer stalls after single patient
Disease control TerminatedThis early-phase trial tested a combination of two drugs—icosapent ethyl (an omega-3 fatty acid) and dasatinib (a targeted cancer drug)—in people with a rare, aggressive form of breast cancer that had spread. The goal was to find a safe dose and see if the combo could shrink tumo…
Matched conditions: ANATOMIC STAGE IV BREAST CANCER AJCC V8
Phase: PHASE1, PHASE2 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated Jun 27, 2026 07:53 UTC
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Promising combo study for HER2+ breast cancer halted early
Disease control TerminatedThis study looked at adding a drug called copanlisib to standard targeted therapy (trastuzumab and pertuzumab) for people with HER2-positive breast cancer that had spread and had specific gene changes (PIK3CA or PTEN). The goal was to see if the combination was safe and could hel…
Matched conditions: ANATOMIC STAGE IV BREAST CANCER AJCC V8
Phase: PHASE1, PHASE2 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated Jun 27, 2026 07:53 UTC
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Can meal timing protect your brain during cancer treatment?
Symptom relief TerminatedThis study tested a text-message-based diet program called Txt4fasting for people with breast or lung cancer that spread to the brain. The goal was to see if eating only during certain hours could reduce thinking and memory problems after radiation. Only 1 person enrolled before …
Matched conditions: ANATOMIC STAGE IV BREAST CANCER AJCC V8
Phase: NA • Sponsor: Thomas Jefferson University • Aim: Symptom relief
Last updated Jun 27, 2026 09:10 UTC
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Antifungal drug tested against brain tumors – trial stopped early
Knowledge-focused TerminatedThis early-phase trial tested whether the antifungal drug ketoconazole could block a protein called tGLI1 in brain tumors. It included 15 people with breast cancer that spread to the brain or with a type of brain cancer called glioma. The study was terminated early, so we have li…
Matched conditions: ANATOMIC STAGE IV BREAST CANCER AJCC V8
Phase: EARLY_PHASE1 • Sponsor: Wake Forest University Health Sciences • Aim: Knowledge-focused
Last updated Jun 27, 2026 11:03 UTC