Promising combo study for HER2+ breast cancer halted early
NCT ID NCT04108858
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study looked at adding a drug called copanlisib to standard targeted therapy (trastuzumab and pertuzumab) for people with HER2-positive breast cancer that had spread and had specific gene changes (PIK3CA or PTEN). The goal was to see if the combination was safe and could help control the cancer longer. Only 2 people enrolled before the study was stopped, so results are very limited.
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Los Angeles County-USC Medical Center
Los Angeles, California, 90033, United States
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M D Anderson Cancer Center
Houston, Texas, 77030, United States
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UCHealth University of Colorado Hospital
Aurora, Colorado, 80045, United States
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USC / Norris Comprehensive Cancer Center
Los Angeles, California, 90033, United States
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University of Oklahoma Health Sciences Center
Oklahoma City, Oklahoma, 73104, United States