New combo therapy aims to halt spread of aggressive breast cancer
NCT ID NCT06492759
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This phase II trial tests whether adding high-dose radiation to standard immunotherapy (pembrolizumab) and chemotherapy can help control metastatic triple-negative breast cancer that is PD-L1 positive. About 29 participants with at least two sites of metastatic disease will receive the combination. The main goal is to see if this approach improves the time until the cancer progresses.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- pembrolizumab (immunotherapy) plus chemotherapy (paclitaxel, nab-paclitaxel, carboplatin, gemcitabine) and high-dose radiation therapy
- What this could lead to
- If successful, this combination could improve how long the cancer is kept under control in patients with metastatic triple-negative breast cancer.
- What could go wrong
- This is a small, early-phase trial with only 29 participants, so results may not apply broadly. The combination of radiation, immunotherapy, and chemotherapy can cause significant side effects.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Emory University Hospital/Winship Cancer Institute
RECRUITINGAtlanta, Georgia, 30322, United States
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