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Radiation zaps spots to keep chemo working longer

NCT ID NCT06055881

Recruiting now Disease control Sponsor: Mayo Clinic Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This study tests whether precisely targeted radiation (SBRT) can treat a few growing cancer spots in patients with metastatic breast cancer, allowing them to stay on their current systemic therapy instead of switching to a new drug. Researchers will also look at whether circulating tumor cells in the blood can help guide treatment decisions. The trial enrolls 45 adults with stable disease for at least 12 months who develop 1-3 new progressive sites.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
Stereotactic body radiation therapy (SBRT)
What this could lead to
If successful, this approach could allow patients to stay on their current systemic therapy longer, delaying the need for a new drug regimen.
What could go wrong
This is a small, early-phase study (45 participants) with no control group, so results may not apply broadly. Radiation may not effectively control all progressive sites, and side effects from SBRT are possible.

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Conditions

The condition(s) this trial relates to.

breast cancer breast carcinoma breast neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ANATOMIC STAGE IV BREAST CANCER AJCC V8 BREAST CARCINOMA METASTATIC BREAST CANCER

Contacts and locations

Study contacts

  • Contact

    Email: •••••@•••••

Locations

  • Mayo Clinic in Arizona

    RECRUITING

    Scottsdale, Arizona, 85259, United States

    Contact Email: •••••@•••••

  • Mayo Clinic in Rochester

    RECRUITING

    Rochester, Minnesota, 55905, United States

    Contact Email: •••••@•••••

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