Nrg Oncology

This study tests whether giving a higher, more focused dose of radiation (using advanced photon or proton beams) along with the chemotherapy drug temozolomide helps people with newly diagnosed glioblastoma live longer compared to standard radiation. About 600 participants are enr…

This study is for men whose prostate cancer has returned after surgery, shown by a rising PSA. It compares standard radiation therapy alone versus radiation plus a drug called apalutamide, which blocks male hormones that fuel cancer growth. The goal is to see if the combination d…

This study tests whether using a genetic test to personalize hormone therapy can improve outcomes for men with high-risk prostate cancer. For those with a low genetic risk, a shorter course of hormone therapy (12 months instead of 24) is compared to standard care. For those with …

This study compares two types of radiation therapy for people with liver cancer that cannot be removed by surgery or has come back. One type uses standard X-rays (photons), while the other uses proton beams, which may cause less harm to healthy organs nearby. The goal is to see i…

This trial aimed to test whether adding a gene therapy (Toca 511) and a special pill (Toca FC) to standard radiation and chemotherapy could help people with a newly diagnosed aggressive brain cancer called glioblastoma. The treatment was designed to turn cancer cells into drug fa…

This study tests whether a blood test for Epstein-Barr virus (EBV) DNA can help doctors choose the best chemotherapy after standard radiation for nasopharyngeal cancer. About 685 patients with advanced but non-spread cancer will first receive standard chemo and radiation. Then, b…

This study tests whether giving radiation therapy to high-risk but painless bone tumors can prevent future fractures, spinal cord pressure, or the need for surgery. About 280 cancer patients with multiple metastases will receive either usual care (like bone-strengthening drugs or…

This study compares two types of radiation therapy for men with early-stage prostate cancer. One method uses fewer, higher-dose treatments (SBRT), while the other uses more frequent, lower-dose sessions. The goal is to see which approach better controls the cancer while causing f…

This study uses a genetic test (Decipher score) to decide the best treatment for men with a certain type of prostate cancer. For men with a low-risk gene score, the study tests if radiation alone works as well as radiation plus hormone therapy, potentially avoiding hormone side e…

This early-phase trial tests whether adding a cancer-killing virus (OBP-301) to standard chemotherapy and radiation is safe for people with advanced esophageal or gastroesophageal cancer who cannot have surgery. The virus is designed to infect and destroy tumor cells. The study e…

This study tests whether adding the drug relugolix to standard radiation therapy can slow the spread of prostate cancer that has spread to a few other parts of the body. Relugolix lowers testosterone, which can help stop cancer growth. About 194 men with this type of prostate can…

This study compares two different schedules of the chemotherapy drug cisplatin given alongside radiation for people with advanced head and neck cancer. One group gets a high dose every three weeks, the other gets a lower dose every week. The goal is to see which schedule causes f…

This study tests whether the hormone therapy letrozole alone works as well as chemotherapy plus letrozole for people with stage II to IV low-grade serous ovarian, fallopian tube, or peritoneal cancer. Letrozole lowers estrogen, which can slow tumor growth. The trial aims to find …

This study tests whether adding local treatments like radiation or surgery to standard maintenance chemotherapy helps people with stage IV non-small cell lung cancer live longer without the disease getting worse. About 218 participants are randomly assigned to receive either main…

This study tests whether giving focused radiation before surgery for brain metastases works better than the usual approach of radiation after surgery. About 237 adults with 1 to 4 brain tumors will be randomly assigned to one of the two timing schedules. The goal is to see which …

This study tests whether adding a second chemotherapy drug, lomustine, to the standard treatment (temozolomide plus radiation) helps people with a specific type of glioblastoma (a fast-growing brain cancer). The trial includes 265 newly diagnosed patients whose tumors have a gene…

This study looks at whether women (and men) age 40+ with early-stage, low-risk HER2+ breast cancer can safely skip radiation after breast-conserving surgery if they have already received chemotherapy and HER2-targeted therapy. About 1,300 participants will be randomly assigned to…

This study looks at whether a dye called iohexol can help doctors better calculate the dose of the chemotherapy drug carboplatin for cancer patients. Researchers will compare different methods of estimating kidney function to see which gives the most accurate dose. The goal is to…