New study aims to perfect chemo dosing for cancer patients

NCT ID NCT03997370

Knowledge-focused Sponsor: NRG Oncology Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 07, 2026 · Updated 1 time

Summary

This study looks at whether a dye called iohexol can help doctors better calculate the dose of the chemotherapy drug carboplatin for cancer patients. The goal is to make sure patients get the right amount of drug to fight their cancer while reducing side effects. About 318 men with solid tumors are taking part to improve future dosing guidelines.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 1

The first testing in people. Mainly checks safety and dose, usually in a small group.

Participants

About 350 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jan 2020

Expected to finish

Mar 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Male participants only

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients must have the psychological ability and general health that permits completion of the study requirements and required follow up * For men who are sexually active, the need for use of medically acceptable contraception will be dictated by the primary treatment plan/protocol * Study accrual was closed to women on 08/18/2021 and accrual is now only open to males in order to meet accrual goals and study objectives. (11-AUG-2021) * Male sex * Any patients who will receive treatment with intravenous carboplatin (any AUC, any cycle) on a National Cancer Institute (NCI)-sponsored National Clinical Trial Network (NCTN)-, Experimental Therapeutics Clinical Trials Network (ETCTN)-, trial, local trial, or through standard of care * Age \>= 18 * The patient or a legally authorized representative must provide study-specific informed consent prior to study entry Exclusion Criteria: * Treated at an institute where creatinine is not measured with an IDMS calibrated assay * History of allergic reactions to computed tomography (CT) contrast, iodine or shellfish, or history of anaphylactic reaction to any food item * Recent (last 6 months) episode of acute kidney injury, have sickle cell disease, or have current indwelling nephrostomy tubes * Edema beyond trace edema, because this will impact iohexol equilibration and distribution * Ascites (including pleural effusion) beyond trace ascites, because this will impact iohexol equilibration and distribution * Whole- or part-limb amputees, because this will impact iohexol equilibration and distribution * Inability to maintain a constant dose and schedule of anti-inflammatory agents, diuretics, angiotensin II receptor blockers (ARB) and angiotensin converting enzyme inhibitors (ACEi) for one week prior to study visit, as this impacts renal function. If the patient is on a nonsteroidal anti-inflammatory drug (NSAID), diuretic, ARB or ACEi, they are eligible as long as these agents are taken on a set schedule for 7 or more days prior to study (and not on an "as needed" basis as that can cause fluctuations in renal function) * Inadequate venous access to obtain pharmacokinetic (PK) specimens * Multinodular goiter, Graves' disease or autoimmune thyroiditis, per iohexol package insert (hypothyroidism is allowed)

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Conditions

The condition(s) this trial relates to.

cancer

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Malignant solid neoplasm

Contacts and locations

Locations

Armes Family Cancer Center

Findlay, Ohio, 45840, United States
Arnot Ogden Medical Center/Falck Cancer Center

Elmira, New York, 14905, United States
Asplundh Cancer Pavilion

Willow Grove, Pennsylvania, 19090, United States
Atrium Medical Center-Middletown Regional Hospital

Franklin, Ohio, 45005-1066, United States
Banner University Medical Center - Tucson

Tucson, Arizona, 85719, United States
Baystate Medical Center

Springfield, Massachusetts, 01199, United States
Benefis Helena Specialty Center

Helena, Montana, 59601, United States
Benefis Sletten Cancer Institute

Great Falls, Montana, 59405, United States
Billings Clinic Cancer Center

Billings, Montana, 59101, United States
Billings Clinic-Cody

Cody, Wyoming, 82414, United States
Blanchard Valley Hospital

Findlay, Ohio, 45840, United States
Bozeman Health Deaconess Hospital

Bozeman, Montana, 59715, United States
Broadlawns Medical Center

Des Moines, Iowa, 50314, United States
CARTI Cancer Center

Little Rock, Arkansas, 72205, United States
Cancer Care and Hematology-Fort Collins

Fort Collins, Colorado, 80528, United States
Cancer Center-Metro Medical Center Bayamon

Bayamón, 00959-5060, Puerto Rico
Carle BroMenn Medical Center

Normal, Illinois, 61761, United States
Carle Cancer Center

Urbana, Illinois, 61801, United States
Carle Cancer Institute Normal

Normal, Illinois, 61761, United States
Carle Physician Group-Effingham

Effingham, Illinois, 62401, United States
Carle Physician Group-Mattoon/Charleston

Mattoon, Illinois, 61938, United States
Carle at The Riverfront

Danville, Illinois, 61832, United States
Central Care Cancer Center - Bolivar

Bolivar, Missouri, 65613, United States
Central Care Cancer Center - Garden City

Garden City, Kansas, 67846, United States
Central Care Cancer Center - Great Bend

Great Bend, Kansas, 67530, United States
Centro Comprensivo de Cancer de UPR

San Juan, 00927, Puerto Rico
Clara Maass Medical Center

Belleville, New Jersey, 07109, United States
Cleveland Clinic Cancer Center/Fairview Hospital

Cleveland, Ohio, 44111, United States
Cleveland Clinic Foundation

Cleveland, Ohio, 44195, United States
Community Hospital of Anaconda

Anaconda, Montana, 59711, United States
Community Medical Center

Missoula, Montana, 59804, United States
Community Medical Center

Toms River, New Jersey, 08755, United States
Cooperman Barnabas Medical Center

Livingston, New Jersey, 07039, United States
Cox Cancer Center Branson

Branson, Missouri, 65616, United States
CoxHealth South Hospital

Springfield, Missouri, 65807, United States
Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center

Lebanon, New Hampshire, 03756, United States
Dayton Physician LLC - Englewood

Dayton, Ohio, 45415, United States
Dayton Physicians LLC - Troy

Troy, Ohio, 45373, United States
Dayton Physicians LLC-Atrium

Franklin, Ohio, 45005, United States
Dayton Physicians LLC-Miami Valley South

Centerville, Ohio, 45459, United States
Dayton Physicians LLC-Wayne

Greenville, Ohio, 45331, United States
Doctors Cancer Center

Manati, 00674, Puerto Rico
Emory University Hospital Midtown

Atlanta, Georgia, 30308, United States
Emory University Hospital/Winship Cancer Institute

Atlanta, Georgia, 30322, United States
First Dayton Cancer Care

Kettering, Ohio, 45420, United States
Freeman Health System

Joplin, Missouri, 64804, United States
Good Samaritan University Hospital

West Islip, New York, 11795, United States
Great Falls Clinic

Great Falls, Montana, 59405, United States
Greater Dayton Cancer Center

Kettering, Ohio, 45409, United States
HIMA San Pablo Oncologic Hospital

Caguas, 00726, Puerto Rico
Hartford Hospital

Hartford, Connecticut, 06102, United States
Heartland Regional Medical Center

Saint Joseph, Missouri, 64506, United States
Hematology/Oncology Clinic PLLC

Baton Rouge, Louisiana, 70809, United States
Hi-Line Sletten Cancer Center

Havre, Montana, 59501, United States
Highland Hospital

Rochester, New York, 14620, United States
Hillcrest Hospital Cancer Center

Mayfield Heights, Ohio, 44124, United States
Huntsman Cancer Institute/University of Utah

Salt Lake City, Utah, 84112, United States
Idaho Urologic Institute-Meridian

Meridian, Idaho, 83642, United States
Indu and Raj Soin Medical Center

Beavercreek, Ohio, 45431, United States
Instituto Oncologia Moderna Ponce

Ponce, 00716, Puerto Rico
Iowa Lutheran Hospital

Des Moines, Iowa, 50316, United States
Iowa Methodist Medical Center

Des Moines, Iowa, 50309, United States
Jefferson Cherry Hill Hospital

Cherry Hill, New Jersey, 08002, United States
Johns Hopkins University/Sidney Kimmel Cancer Center

Baltimore, Maryland, 21287, United States
Kettering Medical Center

Kettering, Ohio, 45429, United States
Kootenai Clinic Cancer Services - Post Falls

Post Falls, Idaho, 83854, United States
Kootenai Clinic Cancer Services - Sandpoint

Sandpoint, Idaho, 83864, United States
Kootenai Health - Coeur d'Alene

Coeur d'Alene, Idaho, 83814, United States
Lake Regional Hospital

Osage Beach, Missouri, 65065, United States
Lewis Cancer and Research Pavilion at Saint Joseph's/Candler

Savannah, Georgia, 31405, United States
Logan Health Medical Center

Kalispell, Montana, 59901, United States
Medical Center of the Rockies

Loveland, Colorado, 80538, United States
Medical College of Wisconsin

Milwaukee, Wisconsin, 53226, United States
Memorial Hospital of Laramie County

Cheyenne, Wyoming, 82001, United States
Memorial Sloan Kettering Basking Ridge

Basking Ridge, New Jersey, 07920, United States
Memorial Sloan Kettering Bergen

Montvale, New Jersey, 07645, United States
Memorial Sloan Kettering Cancer Center

New York, New York, 10065, United States
Memorial Sloan Kettering Commack

Commack, New York, 11725, United States
Memorial Sloan Kettering Monmouth

Middletown, New Jersey, 07748, United States
Memorial Sloan Kettering Nassau

Uniondale, New York, 11553, United States
Memorial Sloan Kettering Westchester

Harrison, New York, 10604, United States
Mercy Cancer Center - Cape Girardeau

Cape Girardeau, Missouri, 63703, United States
Mercy Clinic-Rolla-Cancer and Hematology

Rolla, Missouri, 65401, United States
Mercy Hospital Fort Smith

Fort Smith, Arkansas, 72903, United States
Mercy Hospital Joplin

Joplin, Missouri, 64804, United States
Mercy Hospital Oklahoma City

Oklahoma City, Oklahoma, 73120, United States
Mercy Hospital Pittsburg

Pittsburg, Kansas, 66762, United States
Mercy Hospital Saint Louis

St Louis, Missouri, 63141, United States
Mercy Hospital South

St Louis, Missouri, 63128, United States
Mercy Hospital Springfield

Springfield, Missouri, 65804, United States
Mercy Hospital Washington

Washington, Missouri, 63090, United States
Mercy Infusion Center - Chippewa

St Louis, Missouri, 63109, United States
Mercy Oncology and Hematology - Clayton-Clarkson

Ballwin, Missouri, 63011, United States
Methodist West Hospital

West Des Moines, Iowa, 50266-7700, United States
Miami Valley Cancer Care and Infusion

Greenville, Ohio, 45331, United States
Miami Valley Hospital

Dayton, Ohio, 45409, United States
Miami Valley Hospital North

Dayton, Ohio, 45415, United States
Miami Valley Hospital South

Centerville, Ohio, 45459, United States
Monmouth Medical Center

Long Branch, New Jersey, 07740, United States
Monongalia Hospital

Morgantown, West Virginia, 26505, United States
Montefiore Medical Center - Moses Campus

The Bronx, New York, 10467, United States
Montefiore Medical Center-Einstein Campus

The Bronx, New York, 10461, United States
Montefiore Medical Center-Weiler Hospital

The Bronx, New York, 10461, United States
Newark Beth Israel Medical Center

Newark, New Jersey, 07112, United States
NorthShore University HealthSystem-Evanston Hospital

Evanston, Illinois, 60201, United States
NorthShore University HealthSystem-Glenbrook Hospital

Glenview, Illinois, 60026, United States
NorthShore University HealthSystem-Highland Park Hospital

Highland Park, Illinois, 60035, United States
Northwestern Medicine Lake Forest Hospital

Lake Forest, Illinois, 60045, United States
Northwestern University

Chicago, Illinois, 60611, United States
OSF Saint Anthony's Health Center

Alton, Illinois, 62002, United States
Ohio State University Comprehensive Cancer Center

Columbus, Ohio, 43210, United States
Oncology Hematology Care Inc-Kenwood

Cincinnati, Ohio, 45236, United States
Orion Cancer Care

Findlay, Ohio, 45840, United States
PROncology

San Juan, 00927, Puerto Rico
Phelps Health Delbert Day Cancer Institute

Rolla, Missouri, 65401, United States
Poudre Valley Hospital

Fort Collins, Colorado, 80524, United States
Primary Care Physician Group

San Juan, 00920, Puerto Rico
Puerto Rico Hematology Oncology Group

Bayamón, 00961, Puerto Rico
Reid Health

Richmond, Indiana, 47374, United States
Robert Wood Johnson University Hospital Somerset

Somerville, New Jersey, 08876, United States
Roswell Park Cancer Institute

Buffalo, New York, 14263, United States
Rutgers Cancer Institute of New Jersey

New Brunswick, New Jersey, 08903, United States
Rutgers New Jersey Medical School

Newark, New Jersey, 07101, United States
SSM Health Good Samaritan

Mount Vernon, Illinois, 62864, United States
Saint Alphonsus Cancer Care Center-Baker City

Baker City, Oregon, 97814, United States
Saint Alphonsus Cancer Care Center-Boise

Boise, Idaho, 83706, United States
Saint Alphonsus Cancer Care Center-Caldwell

Caldwell, Idaho, 83605, United States
Saint Alphonsus Cancer Care Center-Nampa

Nampa, Idaho, 83687, United States
Saint Alphonsus Cancer Care Center-Ontario

Ontario, Oregon, 97914, United States
Saint Anthony Regional Hospital

Carroll, Iowa, 51401, United States
Saint Elizabeth Boardman Hospital

Boardman, Ohio, 44512, United States
Saint Elizabeth Healthcare Edgewood

Edgewood, Kentucky, 41017, United States
Saint Elizabeth Youngstown Hospital

Youngstown, Ohio, 44501, United States
Saint Joseph Warren Hospital

Warren, Ohio, 44484, United States
Saint Joseph's/Candler - Bluffton Campus

Bluffton, South Carolina, 29910, United States
Saint Mary's Hospital

Centralia, Illinois, 62801, United States
San Juan City Hospital

San Juan, 00936, Puerto Rico
San Juan Community Oncology Group

San Juan, 00917, Puerto Rico
Sibley Memorial Hospital

Washington D.C., District of Columbia, 20016, United States
Sidney Kimmel Cancer Center Washington Township

Sewell, New Jersey, 08080, United States
Springfield Regional Cancer Center

Springfield, Ohio, 45504, United States
Springfield Regional Medical Center

Springfield, Ohio, 45504, United States
State University of New York Upstate Medical University

Syracuse, New York, 13210, United States
The Cancer Institute at Saint Francis Hospital

East Hills, New York, 11548, United States
The Carle Foundation Hospital

Urbana, Illinois, 61801, United States
The Hospital of Central Connecticut

New Britain, Connecticut, 06050, United States
Thomas Jefferson University Hospital

Philadelphia, Pennsylvania, 19107, United States
Trinitas Hospital and Comprehensive Cancer Center - Williamson Street Campus

Elizabeth, New Jersey, 07207, United States
Tulane University School of Medicine

New Orleans, Louisiana, 70112, United States
UC Comprehensive Cancer Center at Silver Cross

New Lenox, Illinois, 60451, United States
UC San Diego Health System - Encinitas

Encinitas, California, 92024, United States
UC San Diego Medical Center - Hillcrest

San Diego, California, 92103, United States
UC San Diego Moores Cancer Center

La Jolla, California, 92093, United States
UCHealth Greeley Hospital

Greeley, Colorado, 80631, United States
UCHealth University of Colorado Hospital

Aurora, Colorado, 80045, United States
UI Health Care Mission Cancer and Blood - Ankeny Clinic

Ankeny, Iowa, 50023, United States
UI Health Care Mission Cancer and Blood - Des Moines Clinic

Des Moines, Iowa, 50309, United States
UI Health Care Mission Cancer and Blood - Laurel Clinic

Des Moines, Iowa, 50314, United States
UI Health Care Mission Cancer and Blood - Waukee Clinic

Waukee, Iowa, 50263, United States
UI Health Care Mission Cancer and Blood - West Des Moines Clinic

Clive, Iowa, 50325, United States
UI Healthcare Mission Cancer and Blood - Fort Dodge

Fort Dodge, Iowa, 50501, United States
UPMC Hillman Cancer Center

Pittsburgh, Pennsylvania, 15232, United States
University of Arizona Cancer Center-North Campus

Tucson, Arizona, 85719, United States
University of Arizona Cancer Center-Orange Grove Campus

Tucson, Arizona, 85704, United States
University of Arkansas for Medical Sciences

Little Rock, Arkansas, 72205, United States
University of California Davis Comprehensive Cancer Center

Sacramento, California, 95817, United States
University of Chicago Comprehensive Cancer Center

Chicago, Illinois, 60637, United States
University of Chicago Medicine-Orland Park

Orland Park, Illinois, 60462, United States
University of Cincinnati Cancer Center-UC Medical Center

Cincinnati, Ohio, 45219, United States
University of Cincinnati Cancer Center-West Chester

West Chester, Ohio, 45069, United States
University of Oklahoma Health Sciences Center

Oklahoma City, Oklahoma, 73104, United States
University of Rochester

Rochester, New York, 14642, United States
University of Utah Sugarhouse Health Center

Salt Lake City, Utah, 84106, United States
Upper Valley Medical Center

Troy, Ohio, 45373, United States
VCU Massey Cancer Center at Stony Point

Richmond, Virginia, 23235, United States
VCU Massey Comprehensive Cancer Center

Richmond, Virginia, 23298, United States
Vanderbilt Breast Center at One Hundred Oaks

Nashville, Tennessee, 37204, United States
Vanderbilt University/Ingram Cancer Center

Nashville, Tennessee, 37232, United States
Vanderbilt-Ingram Cancer Center Cool Springs

Franklin, Tennessee, 37067, United States
Vanderbilt-Ingram Cancer Center at Franklin

Franklin, Tennessee, 37067, United States
Walter Knox Memorial Hospital

Emmett, Idaho, 83617, United States
Walter Reed National Military Medical Center

Bethesda, Maryland, 20889-5600, United States
Wayne Hospital

Greenville, Ohio, 45331, United States
Wayne State University/Karmanos Cancer Institute

Detroit, Michigan, 48201, United States
Weisberg Cancer Treatment Center

Farmington Hills, Michigan, 48334, United States
Welch Cancer Center

Sheridan, Wyoming, 82801, United States
West Penn Hospital

Pittsburgh, Pennsylvania, 15224, United States
Women and Infants Hospital

Providence, Rhode Island, 02905, United States
Women's Cancer Center of Nevada

Las Vegas, Nevada, 89106, United States

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