New drug combo aims to stop prostate cancer spread after surgery

NCT ID NCT04134260

Ongoing Disease control Sponsor: NRG Oncology Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This phase III trial tests whether adding the drug apalutamide to standard hormone therapy and radiation helps men with prostate cancer that has spread to nearby lymph nodes after surgery. About 586 participants will receive either the usual treatment or the usual treatment plus apalutamide. The goal is to see if the combination delays cancer from spreading further and improves quality of life.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

Apalutamide (a drug that blocks male hormones from fueling prostate cancer growth)

What this could lead to

If successful, adding apalutamide to standard hormone therapy and radiation could delay or prevent prostate cancer from spreading, giving patients more time without disease progression.

What could go wrong

This is a large phase III trial, but results are not yet available. Apalutamide may cause side effects like fatigue, high blood pressure, or falls, and it may not improve outcomes for all patients.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

metastatic prostate carcinoma prostate adenocarcinoma prostate cancer prostate carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PROSTATE ADENOCARCINOMA STAGE I PROSTATE CANCER AJCC V8 STAGE II PROSTATE CANCER AJCC V8 STAGE III PROSTATE CANCER AJCC V8 STAGE IVA PROSTATE CANCER AJCC V8

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Wake Forest University Health Sciences

Winston-Salem, North Carolina, 27157, United States
Washington University School of Medicine

St Louis, Missouri, 63110, United States
West Virginia University Charleston Division

Charleston, West Virginia, 25304, United States
Western Illinois Cancer Treatment Center

Galesburg, Illinois, 61401, United States
Wilmot Cancer Institute Radiation Oncology at Greece

Rochester, New York, 14606, United States
Wilmot Cancer Institute at Webster

Webster, New York, 14580, United States
Woodland Memorial Hospital

Woodland, California, 95695, United States