Diabetes drug takes on brain cancer: can sitagliptin unleash the immune system?

NCT ID NCT07003542

First seen May 09, 2026 · Last updated May 09, 2026

Summary

This study tests whether sitagliptin, a diabetes drug, can improve the immune system's ability to fight glioblastoma, an aggressive brain cancer. About 48 adults with progressive grade 4 glioma who are scheduled for tumor removal surgery will receive sitagliptin or no pre-surgery treatment. The goal is to see if sitagliptin increases cancer-fighting immune cells in the tumor and improves survival.

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Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Case Comprehensive Cancer Center, Cleveland Clinic Foundation Taussig Cancer Institute

    RECRUITING

    Cleveland, Ohio, 44195, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

Conditions

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