Sound waves open brain barrier to attack deadly tumors
NCT ID NCT05902169
First seen Oct 31, 2025 · Last updated May 01, 2026 · Updated 24 times
Summary
This phase 3 trial tests whether a device called SonoCloud-9 can temporarily open the blood-brain barrier, allowing more chemotherapy (carboplatin) to reach brain tumors in people with recurrent glioblastoma. About 560 participants will be randomly assigned to receive either carboplatin plus the ultrasound device or standard chemotherapy. The main goal is to see if this approach helps people live longer.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Azienda Ospedaliero Universitaria Città della Salute e della Scienza di Torino
ACTIVE_NOT_RECRUITINGTorino, 10126, Italy
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CHU de Liège
RECRUITINGLiège, Belgium
Contact
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Centre Hospitalier Universitaire Vaudois (CHUV)
ACTIVE_NOT_RECRUITINGLausanne, 1011, Switzerland
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Charité Universitätsmedizin Berlin
ACTIVE_NOT_RECRUITINGBerlin, 10117, Germany
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Erasmus Medisch Centrum (Erasmus MC)
ACTIVE_NOT_RECRUITINGRotterdam, Netherlands
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Haaglanden Medisch Centrum
ACTIVE_NOT_RECRUITINGThe Hague, 2263, Netherlands
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Hospital Clinic de Barcelona
ACTIVE_NOT_RECRUITINGBarcelona, 08036, Spain
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Hospital Universitario 12 de Octubre
ACTIVE_NOT_RECRUITINGMadrid, Spain
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Hospital Universitario HM Sanchinarro
ACTIVE_NOT_RECRUITINGMadrid, 28050, Spain
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Hospital Universitario Virgen del Rocío
ACTIVE_NOT_RECRUITINGSeville, 41013, Spain
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Hôpital Foch
ACTIVE_NOT_RECRUITINGSuresnes, 92150, France
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Hôpital Neurologique Pierre Wertheimer
ACTIVE_NOT_RECRUITINGBron, France
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Hôpital de La Timone
RECRUITINGMarseille, France
Contact
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Hôpital de la Pitié-Salpêtrière
RECRUITINGParis, France
Contact
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Indiana University Health
ACTIVE_NOT_RECRUITINGIndianapolis, Indiana, 46202, United States
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Inselspital Bern
ACTIVE_NOT_RECRUITINGBern, 3010, Switzerland
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Irccs Istituto Clinico Humanitas
ACTIVE_NOT_RECRUITINGRozzano, 20089, Italy
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Istituto Oncologico Veneto
ACTIVE_NOT_RECRUITINGPadua, Italy
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John Hopkins University
ACTIVE_NOT_RECRUITINGBaltimore, Maryland, 21287, United States
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Klinikum Chemnitz gGmbH
ACTIVE_NOT_RECRUITINGChemnitz, 09113, Germany
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Lennox Hill Hospital
ACTIVE_NOT_RECRUITINGNew York, New York, 10075, United States
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Mayo Clinic Arizona
ACTIVE_NOT_RECRUITINGPhoenix, Arizona, 805054, United States
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Mayo Clinic Rochester
ACTIVE_NOT_RECRUITINGRochester, Minnesota, 55905, United States
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Mayo Clinic of Jacksonville Florida
ACTIVE_NOT_RECRUITINGJacksonville, Florida, 32224, United States
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Medizinische Universitaet Innsbruck
ACTIVE_NOT_RECRUITINGInnsbruck, 6020, Austria
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Miami Cancer Institute
ACTIVE_NOT_RECRUITINGMiami, Florida, 33176, United States
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Moffitt Cancer Center
ACTIVE_NOT_RECRUITINGTampa, Florida, 33612, United States
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Neurochirurgie uniklinik Köln
ACTIVE_NOT_RECRUITINGCologne, Germany
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NewYork-Presbyterian / Columbia University Irving Medical Center
ACTIVE_NOT_RECRUITINGNew York, New York, 10032, United States
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Northwestern University
ACTIVE_NOT_RECRUITINGChicago, Illinois, 60611, United States
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Odense University Hospital
ACTIVE_NOT_RECRUITINGOdense, 5000, Denmark
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Ospedale Bellaria
ACTIVE_NOT_RECRUITINGBologna, 40139, Italy
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Ospedale Civile di Livorno
ACTIVE_NOT_RECRUITINGLivorno, 57124, Italy
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Penn State Health Milton S. Hershey Medical Center
ACTIVE_NOT_RECRUITINGHershey, Pennsylvania, 17033, United States
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Rigshospitalet
ACTIVE_NOT_RECRUITINGCopenhagen, 2100, Denmark
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UCHealth
ACTIVE_NOT_RECRUITINGAurora, Colorado, 80011, United States
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Universitair Ziekenhuis Brussel
RECRUITINGBrussels, Belgium
Contact
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Universitair Ziekenhuis Leuven
ACTIVE_NOT_RECRUITINGLeuven, Belgium
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University of California, San Francisco
ACTIVE_NOT_RECRUITINGSan Francisco, California, 94143, United States
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University of North Carolina
ACTIVE_NOT_RECRUITINGChapel Hill, North Carolina, 27516, United States
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University of Texas Houston Health Science Center
ACTIVE_NOT_RECRUITINGHouston, Texas, 77030, United States
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University of Texas Southwestern Medical Center
ACTIVE_NOT_RECRUITINGDallas, Texas, 75390, United States
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University of Utah, Hunstman Cancer Institute
ACTIVE_NOT_RECRUITINGSalt Lake City, Utah, 84112, United States
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Universitätsklinikum Carl Gustav Carus Dresden
ACTIVE_NOT_RECRUITINGDresden, 01307, Germany
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Universitätsklinikum Essen Klinik für Neurologie
ACTIVE_NOT_RECRUITINGEssen, 45147, Germany
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Vall d'Hebron Institute of Oncology (VHIO)
ACTIVE_NOT_RECRUITINGBarcelona, 08035, Spain
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Weill Cornell Medicine
ACTIVE_NOT_RECRUITINGNew York, New York, 10021, United States
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Winship Cancer Institute at Emory University
ACTIVE_NOT_RECRUITINGAtlanta, Georgia, 30322, United States
Conditions
Explore the condition pages connected to this study.