Brain cancer trial aims to customize therapy, reduce side effects
NCT ID NCT01878617
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This phase 2 trial tests a personalized approach to treating medulloblastoma, a type of brain cancer. Instead of using a one-size-fits-all treatment, the study assigns radiation and chemotherapy doses based on the tumor's molecular subtype and the patient's risk level. The goal is to see if lower doses can be used for some patients to reduce side effects while maintaining survival, and if adding targeted drugs helps others. The trial enrolled 660 children and young adults across multiple centers.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- radiation therapy and chemotherapy (cyclophosphamide, cisplatin)
- What this could lead to
- If successful, this approach could tailor treatment for medulloblastoma, potentially improving survival while reducing side effects for some patients.
- What could go wrong
- This is a phase 2 trial, so results are not yet proven. The treatment involves significant side effects from radiation and chemotherapy, and not all subgroups may benefit.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Alberta Children's Hospital
Calgary, Alberta, T3B 6A8, Canada
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Arnold Palmer Hospital for Children
Orlando, Florida, 32806, United States
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Centre Hospitalier Universitaire Sainte-Justine
Montreal, Quebec, H3T 1C5, Canada
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Children's Hospital and Clinics of Minnesota
Minneapolis, Minnesota, 55102, United States
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Children's Hospital at Westmead
Westmead, New South Wales, 2145, Australia
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Children's Hospital of Philadelphia
Philadelphia, Pennsylvania, 19104, United States
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Children's National Medical Center
Washington D.C., District of Columbia, 20010, United States
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Cook Children's Medical Center
Fort Worth, Texas, 76104, United States
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Duke Children's Hospital and Health Center
Durham, North Carolina, 27710, United States
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Lucille Packard Children's Hospital at Stanford University Medical Center
Palo Alto, California, 94304, United States
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Medical University of South Carolina
Charleston, South Carolina, 29425, United States
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Perth Children's Hospital
Perth, Western Australia, 6008, Australia
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Queensland Children's Hospital
Brisbane, Queensland, 4029, Australia
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Rady Children's Hospital
San Diego, California, 92123, United States
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Royal Children's Hospital, Melbourne
Melbourne, Victoria, 3052, Australia
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St. Jude Children's Research Hospital
Memphis, Tennessee, 38105, United States
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Starship Children's Hospital
Auckland, 1142, New Zealand
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Sydney Children's Hospital
Randwick, New South Wales, 2031, Australia
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Texas Children's Cancer Center
Houston, Texas, 77030-2399, United States
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The Hospital for Sick Children
Toronto, Ontario, M5G 1X8, Canada
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University of Florida
Gainesville, Florida, 32611, United States
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University of Texas Southwestern Medical Center
Dallas, Texas, 75390, United States
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Yale University
New Haven, Connecticut, 06520, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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- Scientists probe MYC gene's weak spots in aggressive childhood brain cancer