Intensive chemo combo shows promise for kids with aggressive brain cancer
NCT ID NCT02875314
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether giving three rounds of very strong chemotherapy with stem cell rescue works better than one round for children under 10 with high-risk brain tumors. The goal is to improve survival without adding too many side effects. About 250 children will take part.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for CENTRAL NERVOUS SYSTEM EMBRYONAL TUMORS are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Show contact details
Enter your email to view the contact information for this study.
By submitting, you agree to our Terms of use
Locations
-
Akron Children's Hospital
Akron, Ohio, 44308, United States
-
Alberta Children's Hospital
Calgary, Canada
-
American Family Children's Hospital/University of Wisconsin
Madison, Wisconsin, 53792, United States
-
Arkansas Children's Hospital
Little Rock, Arkansas, 72202, United States
-
B.C. Children's Hospital
Vancouver, British Columbia, V6H 3V4, Canada
-
Carolina's HealthCare System/Levine Cancer Institute
Charlotte, North Carolina, 28204, United States
-
Central Michigan University
Detroit, Michigan, 48201, United States
-
Children's Healthcare of Atlanta
Atlanta, Georgia, 30342, United States
-
Children's Hospital Colorado
Aurora, Colorado, 80045, United States
-
Children's Hospital Los Angeles
Los Angeles, California, 90027, United States
-
Children's Hospital Orange County
Orange, California, 91868, United States
-
Children's Hospital of Minnesota
Minneapolis, Minnesota, 55404, United States
-
Children's Hospital of Philadelphia
Philadelphia, Pennsylvania, 19104, United States
-
Children's National Medical Center
Washington D.C., District of Columbia, 20010, United States
-
Children's Specialty Care of Nevada
Las Vegas, Nevada, 89135, United States
-
Children's of Alabama
Birmingham, Alabama, 35233, United States
-
Christchurch Children's Hospital
Christchurch, New Zealand
-
Cleveland Clinic
Cleveland, Ohio, 44195, United States
-
Columbia Presbyterian Children's Hospital
New York, New York, 10032, United States
-
Dana Farber Cancer Institute
Boston, Massachusetts, 02215, United States
-
Dayton Children's Hospital
Dayton, Ohio, 45404, United States
-
Duke University Medical Center
Durham, North Carolina, 27710, United States
-
Hamilton Health/McMasters Children's Hospital, Hamilton, Canada
Hamilton, Canada
-
Helen DeVos Children's Hospital
Grand Rapids, Michigan, 49503, United States
-
John's Hopkins All Children's Hospital
St. Petersburg, Florida, 33701, United States
-
John's Hopkins University School of Medicine
Baltimore, Maryland, 21287, United States
-
Joseph Sanzari Children's Hospital/ Hackensack University
Hackensack, New Jersey, 07601, United States
-
Loma Linda University Medical Center
Loma Linda, California, 92350, United States
-
MD Anderson Cancer Center
Houston, Texas, 77030, United States
-
Masonic Children's Hospital/University of Minnesota
Minneapolis, Minnesota, 55454, United States
-
Mattel Children's Hospital (UCLA)
Los Angeles, California, 90095, United States
-
Mayo Clinic
Rochester, Minnesota, 55905, United States
-
Medical College of Wisconsin
Milwaukee, Wisconsin, 58226, United States
-
Medical University of South Carolina
Charleston, South Carolina, 29425, United States
-
Memorial Care Health Services
Long Beach, California, 90806, United States
-
Memorial Sloan Kettering Cancer Center
New York, New York, 10065, United States
-
Morristown Medical Center, Atlantic Health System
Morristown, New Jersey, 07960, United States
-
NYU Langone Medical Center
New York, New York, 10016, United States
-
Nationwide Children's Hospital
Columbus, Ohio, 43205, United States
-
Nemours Center for Cancer and Blood Disorders
Wilmington, Delaware, 19803, United States
-
Nemours Center for Cancer and Blood Disorders
Jacksonville, Florida, 19803, United States
-
New York Medical College
Hawthorne, New York, 10532, United States
-
Nicklaus Children's Hospital
Miami, Florida, 33155, United States
-
Northwell Health
Hempstead, New York, 11549, United States
-
Orlando Health
Orlando, Florida, 32806, United States
-
Penn State Hershey Children's Hospital
Hershey, Pennsylvania, 17033, United States
-
Phoenix Children's Hospital
Phoenix, Arizona, 85016, United States
-
Primary Children's Hospital
Salt Lake City, Utah, 84113, United States
-
Rainbow Babies & Children's Hospital
Cleveland, Ohio, 44106, United States
-
Riley Children's Hospital/University of Indiana
Indianapolis, Indiana, 46202, United States
-
Shands Children's Hospital/ University of FL
Gainesville, Florida, 32608, United States
-
Starship Children's Hospital
Auckland, New Zealand
-
Stollery Children's Hospital
Edmonton, Canada
-
The Hospital of Sick Children
Toronto, Canada
-
UCSF Oakland Benioff
Oakland, California, 94609, United States
-
University of Iowa Hospital and Clinics
Iowa City, Iowa, 52242, United States
-
University of Louisville School of Medicine
Louisville, Kentucky, 40202, United States
-
University of Michigan
Ann Arbor, Michigan, 48109, United States
-
Upstate Golisano Children's Hospital/ SUNY Upstate Medical University
Syracuse, New York, 13210, United States
-
Vanderbilt-Ingram Cancer Center
Nashville, Tennessee, 37232, United States
-
Virginia Commonwealth University
Richmond, Virginia, 23219, United States
-
Washington University School of Medicine
St Louis, Missouri, 63110, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- AI reads MRI scans to reveal hidden brain tumor types in children before surgery
- Targeted radiation zaps childhood brain tumors in early trial
- Scientists probe MYC gene's weak spots in aggressive childhood brain cancer
- Parental distress may undermine treatment in children with recurrent brain tumors
- New combination therapy aims to outsmart aggressive childhood brain cancer
- Can less radiation still beat childhood brain cancer?