Can a Two-Drug combo beat tough childhood cancers?

This phase 2 trial is testing whether combining two chemotherapy drugs, gemcitabine and oxaliplatin, can shrink tumors in children and adolescents with certain solid cancers that have come back or not responded to standard treatment. The study includes patients with medulloblastoma, other central nervous system tumors, neuroblastoma, and osteosarcoma. Participants receive the drug combination for several cycles, and researchers measure how many achieve a complete or partial response, along with how long the benefit lasts and overall survival.