New RNA vaccine takes on deadly brain cancers in kids and adults

NCT ID NCT04573140

Recruiting now Disease control Sponsor: University of Florida Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This early-phase trial tests a personalized RNA vaccine made from each patient's own tumor. It aims to teach the immune system to attack the cancer. The study includes adults with glioblastoma and children with high-grade gliomas or medulloblastoma. The main goals are to see if the vaccine can be made reliably and if it is safe.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: personalized RNA-lipid particle vaccine
What this could lead to: If successful, this could lead to a new treatment option that uses the patient's own tumor to create a personalized vaccine, potentially helping the immune system fight the cancer.
What could go wrong: This is an early phase 1 trial with only 28 participants, so it is primarily testing safety and manufacturing feasibility. The vaccine may not shrink tumors or extend survival, and there are risks of serious side effects like cytokine release syndrome or neurological toxicity.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

adult glioblastoma brain cancer follicular lymphoma glioblastoma glioma malignant glioma medulloblastoma pediatric high-grade glioma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ADULT GLIOBLASTOMA HIGH GRADE GLIOMA WHO GRADE III OR IV MALIGNANT GLIOMA

Contacts and locations

Locations

Children's National Hospital
RECRUITING

Washington D.C., District of Columbia, 20010, United States
UF Health
RECRUITING

Gainesville, Florida, 32610, United States

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