New RNA vaccine takes on deadly brain cancers in kids and adults
NCT ID NCT04573140
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This early-phase trial tests a personalized RNA vaccine made from each patient's own tumor. It aims to teach the immune system to attack the cancer. The study includes adults with glioblastoma and children with high-grade gliomas or medulloblastoma. The main goals are to see if the vaccine can be made reliably and if it is safe.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
personalized RNA-lipid particle vaccine
What this could lead to
If successful, this could lead to a new treatment option that uses the patient's own tumor to create a personalized vaccine, potentially helping the immune system fight the cancer.
What could go wrong
This is an early phase 1 trial with only 28 participants, so it is primarily testing safety and manufacturing feasibility. The vaccine may not shrink tumors or extend survival, and there are risks of serious side effects like cytokine release syndrome or neurological toxicity.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Children's National Hospital
RECRUITINGWashington D.C., District of Columbia, 20010, United States
Contact Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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UF Health
RECRUITINGGainesville, Florida, 32610, United States
Contact
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••