Can PET-MRI spot hidden brain tumors in kids?

NCT ID NCT05553899

Recruiting now Knowledge-focused Sponsor: Sheffield Children's NHS Foundation Trust Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This pilot study is testing whether a combined PET-MRI scan can better detect if a child's brain tumor has returned after treatment. The study will include 5 children with high-grade gliomas or medulloblastomas who have unclear results from standard MRI. The main goal is to see if such a study is feasible, not yet to prove the method works.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: PET-MRI with 18F-FDG tracer
What this could lead to: If successful, this could show that PET-MRI is a better way to spot tumor recurrence in children, potentially improving follow-up care.
What could go wrong: This is a very small pilot study with only 5 participants, so results may not apply widely. It is testing feasibility, not effectiveness, and may not lead to changes in practice.

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Conditions

The condition(s) this trial relates to.

brain cancer malignant glioma medulloblastoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BRAIN TUMOR, PEDIATRIC

Contacts and locations

Locations

Sheffield Children's Hospital
RECRUITING

Sheffield, South Yorkshire, S10 1SN, United Kingdom

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