New hope for kids with aggressive brain cancer: drug aims to stop relapse
NCT ID NCT04696029
First seen Jun 27, 2026 · Last updated Aug 13, 2026 · Updated 2 times
Summary
This study tests a drug called DFMO (eflornithine) as a maintenance therapy to prevent medulloblastoma, a type of brain cancer, from returning in children. It includes 118 participants aged 0-21 with high-risk or relapsed forms of the disease. The goal is to see if DFMO can extend the time without cancer progression compared to past outcomes.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Advocate Aurora Research Institute
RECRUITINGChicago, Illinois, 60453, United States
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All Children's Hospital Johns Hopkins Medicine
RECRUITINGSt. Petersburg, Florida, 33701, United States
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Arkansas Children's Hospital
RECRUITINGLittle Rock, Arkansas, 72202, United States
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Arnold Palmer Hospital for Children
RECRUITINGOrlando, Florida, 32806, United States
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CHUQ
RECRUITINGQuébec, Quebec, QC G1V 4W6, Canada
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Cardinal Glennon Children's Medical Center
RECRUITINGSt Louis, Missouri, 63104, United States
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Children's Mercy Hospitals and Clinics
RECRUITINGKansas City, Missouri, 64108, United States
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Connecticut Children's Hospital
RECRUITINGHartford, Connecticut, 06106, United States
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Dell Children's Blood and Cancer Center
RECRUITINGAustin, Texas, 78723, United States
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Duke University
RECRUITINGDurham, North Carolina, 27708, United States
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Hackensack University Medical Center
RECRUITINGHackensack, New Jersey, 07601, United States
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Hasbro Children's Hospital
RECRUITINGProvidence, Rhode Island, 02903, United States
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Kapiolani Medical Center for Women and Children
RECRUITINGHonolulu, Hawaii, 96813, United States
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Kentucky Children's Hospital
RECRUITINGLexington, Kentucky, 40502, United States
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Levine Children's Hospital
RECRUITINGCharlotte, North Carolina, 28204, United States
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Medical University of South Carolina
RECRUITINGCharleston, South Carolina, 29425, United States
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Nicklaus Children's Hospital
RECRUITINGMiami, Florida, 33155, United States
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Norton Children's Research Institute/Affiliated with University of Louisville School of Medicine
RECRUITINGLouisville, Kentucky, 40202, United States
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Penn State Milton S. Hershey Medical Center and Children's Hospital
RECRUITINGHershey, Pennsylvania, 17033, United States
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Rady Children's Hospital
RECRUITINGSan Diego, California, 92123, United States
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Randall Children's Hospital
RECRUITINGPortland, Oregon, 97227, United States
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St. Joseph's Children's Hospital
RECRUITINGTampa, Florida, 33607, United States
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Stanford University
RECRUITINGStanford, California, 94305, United States
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UC Davis Comprehensive Cancer Center
RECRUITINGSacramento, California, 95817, United States
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UCSF Benioff Children's Hospital Oakland
RECRUITINGOakland, California, 94609, United States
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University of Oklahoma
RECRUITINGOklahoma City, Oklahoma, 73104, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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- Scientists probe MYC gene's weak spots in aggressive childhood brain cancer