Giselle Sholler

This study tests a two-part approach for children newly diagnosed with high-risk neuroblastoma, a serious nerve cancer. First, doctors use genetic tests to pick personalized drugs during initial chemotherapy. Then, patients receive standard immunotherapy either alone or with an e…

This study tests whether combining two drugs, DFMO and etoposide, can help children and young adults up to age 30 whose neuroblastoma has returned or not responded to standard treatment. The goal is to see if the combination improves how long participants live without the cancer …

This study tests a new pill (tipifarnib) plus an approved IV drug (naxitamab) for children and adults with neuroblastoma that has come back or not responded to treatment. The goal is to see if the combination is safe and shrinks tumors or delays the cancer's return. About 98 part…

This study offers expanded access to the drug DFMO for children and young adults (ages 0-30) with rare, relapsed tumors like neuroblastoma and medulloblastoma. The drug targets tumors with specific genetic markers (LIN28, MYCN, or ODC). The goal is to provide treatment when no ot…

This study tests a drug called DFMO as a maintenance therapy to prevent cancer from coming back in children with high-risk medulloblastoma. The trial enrolls 118 participants aged 0-21 who have molecular high-risk, very high-risk, or relapsed/refractory disease. Researchers will …

This study tests an oral drug called DFMO in children and young adults with high-risk neuroblastoma who are currently in remission. The goal is to see if taking DFMO for two years can prevent the cancer from returning. About 441 participants will take the drug twice daily and be …

This study is for children newly diagnosed with high-risk neuroblastoma, a serious nerve cell cancer. Researchers are adding a drug called naxitamab to the usual chemotherapy to see if it helps more tumors shrink or disappear. About 93 children will take part, and the goal is to …

This study is creating a large database of tumor samples and health information from children and young adults with cancer. Researchers will analyze the genetic makeup of these tumors to find patterns and potential new treatment targets. The goal is to better understand pediatric…