Promising antibody added to standard chemo for tough childhood cancer
NCT ID NCT05489887
First seen Jun 27, 2026 · Last updated Jul 01, 2026 · Updated 1 time
Summary
This phase II trial is testing whether adding the drug naxitamab (Danyelza) to standard chemotherapy improves outcomes for children newly diagnosed with high-risk neuroblastoma. About 93 participants will receive naxitamab during five cycles of induction chemo. The goal is to see if more children achieve a complete response and have better survival compared to past treatments.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Naxitamab (Danyelza), a monoclonal antibody that targets GD2 on cancer cells
What this could lead to
If successful, adding naxitamab early in treatment could improve response rates and survival for children with high-risk neuroblastoma.
What could go wrong
This is a phase II trial with a modest size (93 participants) and no control group—results are compared to historical data. Side effects from naxitamab, like pain and allergic reactions, are possible.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
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Locations
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Arkansas Children's Hospital
RECRUITINGLittle Rock, Arkansas, 72202, United States
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Arnold Palmer Hospital for Children
RECRUITINGOrlando, Florida, 32806, United States
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Augusta University Health
RECRUITINGAugusta, Georgia, 30912, United States
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CHUQ
RECRUITINGQuébec, Quebec, QC G1V 4W6, Canada
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CIUSSS de l'Estrie-CHUS
RECRUITINGSherbrooke, Quebec, QC J1H 5H3, Canada
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Cardinal Glennon Children's Hospital
RECRUITINGSt Louis, Missouri, 63104, United States
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Children's Hospital and Clinics of Minnesota
RECRUITINGMinneapolis, Minnesota, 55404, United States
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Connecticut Children's Hospital
RECRUITINGHartford, Connecticut, 06106, United States
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Dell Children's Blood and Cancer Center
RECRUITINGAustin, Texas, 78723, United States
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GRAACC Hospital
RECRUITINGSão Paulo, 04039-001, Brazil
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Hospital Sant Joan de Déu
RECRUITINGEsplugues de Llobregat, Barcelona, 08950, Spain
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Kapiolani Medical Center for Women and Children
RECRUITINGHonolulu, Hawaii, 96813, United States
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Levine Children's Hospital
RECRUITINGCharlotte, North Carolina, 28204, United States
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Medical University of South Carolina
RECRUITINGCharleston, South Carolina, 29425, United States
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Nicklaus Children's Hospital
RECRUITINGMiami, Florida, 33155, United States
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Norton Children's Research Institute/Affiliated with University of Louisville School of Medicine
RECRUITINGLouisville, Kentucky, 40202, United States
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Penn State Milton S. Hershey Medical Center and Children's Hospital
RECRUITINGHershey, Pennsylvania, 17033, United States
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Rady Children's Hospital
RECRUITINGSan Diego, California, 92123, United States
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Randall Children's Hospital
RECRUITINGPortland, Oregon, 97227, United States
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UCSF Benioff Children's Hospital Oakland
RECRUITINGOakland, California, 94609, United States
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UHC Sainte-Justine
RECRUITINGMontreal, Quebec, QC H3S 2G4, Canada
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University of Alabama/Children's of Alabama
RECRUITINGBirmingham, Alabama, 35201, United States
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University of Florida
RECRUITINGGainesville, Florida, 32611, United States
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Virginia Commonwealth University
RECRUITINGRichmond, Virginia, 23284, United States
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Wake Forest University Health Sciences
WITHDRAWNWinston-Salem, North Carolina, 27157, United States