New hope for kids with aggressive cancer: tailored therapy trial launches

NCT ID NCT02559778

Recruiting now Disease control Sponsor: Giselle Sholler Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study is for children newly diagnosed with high-risk neuroblastoma, a rare and aggressive nerve cancer. It uses genetic testing to choose personalized chemotherapy, then tests whether adding the drug DFMO to standard immunotherapy helps prevent relapse. About 500 children will take part to see if this approach improves how long they stay cancer-free.

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Conditions

The condition(s) this trial relates to.

neuroblastoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

NEUROBLASTOMA

Contacts and locations

Locations

Advocate Aurora Research Institute
COMPLETED

Chicago, Illinois, 60453, United States
Alberta Children's Hospital
RECRUITING

Calgary, Alberta, AB T3B 6A8, Canada
Arkansas Children's Hospital
RECRUITING

Little Rock, Arkansas, 72202, United States
Arnold Palmer Hospital for Children
RECRUITING

Orlando, Florida, 32806, United States
Augusta University Health
RECRUITING

Augusta, Georgia, 30912, United States
CHU Sainte-Justine
RECRUITING

Montreal, Quebec, QC H3S 2G4, Canada
CHUQ
RECRUITING

Québec, Quebec, QC G1V 4W6, Canada
CIUSSS de l'Estrie-CHUS
RECRUITING

Sherbrooke, Quebec, QC J1H 5H3, Canada
Cardinal Glennon Children's Medical Center
RECRUITING

St Louis, Missouri, 63104, United States
Children's Hospital and Clinics of Minnesota
RECRUITING

Minneapolis, Minnesota, 55404, United States
Children's Medical Center
RECRUITING

Dallas, Texas, 75235, United States
Children's Mercy Hospitals and Clinics
COMPLETED

Kansas City, Missouri, 64108, United States
Connecticut Children's Hospital
RECRUITING

Hartford, Connecticut, 06106, United States
Dell Children's Blood and Cancer Center
RECRUITING

Austin, Texas, 78723, United States
Hackensack University Medical Center
COMPLETED

Hackensack, New Jersey, 07601, United States
Helen DeVos Children's Hospital
RECRUITING

Grand Rapids, Michigan, 49503, United States
Kapiolani Medical Center for Women and Children
RECRUITING

Honolulu, Hawaii, 96813, United States
Levine Children's Hospital
RECRUITING

Charlotte, North Carolina, 28204, United States
Medical University of South Carolina
RECRUITING

Charleston, South Carolina, 29425, United States
Nicklaus Children's Miami
RECRUITING

Miami, Florida, 33155, United States
Norton Children's Research Institute/Affiliated with University of Louisville School of Medicine
RECRUITING

Louisville, Kentucky, 40202, United States
Penn State Milton S. Hershey Medical Center and Children's Hospital
RECRUITING

Hershey, Pennsylvania, 17033, United States
Rady Children's Hospital
RECRUITING

San Diego, California, 92123, United States
Randall Children's Hospital
RECRUITING

Portland, Oregon, 97227, United States
St. Joseph's Children's Hospital
RECRUITING

Tampa, Florida, 33614, United States
St. Lukes
COMPLETED

Boise, Idaho, 83712, United States
UCSF Benioff Children's Hospital Oakland
RECRUITING

Oakland, California, 94609, United States
University of Alabama/Children's of Alabama
RECRUITING

Birmingham, Alabama, 35233, United States

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