New balloon coated with paclitaxel aims to keep brain arteries open

NCT ID NCT06047964

Ongoing Disease control Sponsor: B. Braun Medical International Trading Company Ltd. Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests a special balloon catheter coated with the drug paclitaxel to treat narrowed or re-narrowed brain arteries. The balloon is inflated inside the artery to open it and release the drug, which may help prevent the artery from closing again. The trial includes 281 adults aged 18 to 80 with symptomatic intracranial atherosclerosis or restenosis after prior treatment. Researchers will measure how often the artery narrows again and track patients' disability levels over 12 months.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: paclitaxel-coated balloon catheter
What this could lead to: If successful, this could offer a new way to reopen narrowed brain arteries and reduce the risk of stroke in patients with intracranial atherosclerosis.
What could go wrong: This is an early-stage device trial without a randomized control group, so results may not confirm superiority over standard balloons. Risks include vessel injury or restenosis despite treatment.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

intracranial arterial disease intracranial arteriosclerosis stroke disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

INTRACRANIAL ATHEROSCLEROTIC STENOSIS STROKE

Contacts and locations

Locations

First Hospital of Shanxi Medical University

Taiyuan, Shanxi, China
Jining First People's Hospital

Jining, Shandong, China
Nanyang Central Hospital

Nanyang, Henan, China
Renji Hospital, Shanghai Jiaotong University, School of Medicine

Shanghai, Shanghai Municipality, China
The Affiliated Hospital of Qingdao University

Qingdao, Shandong, China
The First Affiliated Hospital of Harbin Medical University

Harbin, Heilongjiang, China
The First Hospital of Jilin University

Changchun, Jilin, China
The Second Affiliated Hospital Zhejiang University School of Medicine

Hangzhou, Zhejiang, China
Xuanwu Hospital, Capital Medical University

Beijing, Beijing Municipality, 100000, China

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