Heart device aims to cut stroke risk without lifelong pills
NCT ID NCT04684212
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study was designed to test a device called LAmbre Plus, which is implanted to seal off a small pouch in the heart where clots can form in people with atrial fibrillation. The goal was to see if it could safely prevent strokes in patients with large or irregularly shaped heart pouches who are at high risk. However, the trial was withdrawn before any participants were enrolled, so no results are available.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
LAmbre Plus Left Atrial Appendage Closure System (a device implanted to seal off part of the heart)
What this could lead to
If successful, this device could offer a stroke-prevention option for people with atrial fibrillation who cannot take blood thinners long-term.
What could go wrong
The trial was withdrawn before enrolling anyone, so no data exists. Device procedures carry risks like bleeding, heart perforation, or device movement.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Henry Ford Hospital
Detroit, Michigan, 48202, United States