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Zapping the brain to fix balance after stroke

NCT ID NCT06747676

Disease control Sponsor: University of Sao Paulo Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused This study
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 10, 2026 · Last updated Jul 10, 2026

Summary

This study tests whether a gentle, targeted electrical stimulation to the brain (HD-tDCS) can safely improve how stroke survivors perceive vertical balance. Participants who have had a stroke affecting one side of the brain will receive either active or sham stimulation while performing visual tasks. The goal is to see if this approach can correct errors in judging what is upright, which may help with balance and daily activities.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
High-Definition transcranial Direct Current Stimulation (HD-tDCS)
What this could lead to
If it works, this could point toward a non-invasive treatment to improve balance and spatial awareness after stroke.
What could go wrong
This is an early-phase study with only 28 participants, so results may not apply broadly. The stimulation may cause mild discomfort or not improve perception.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 1/2

Runs two stages together: safety and dose first, then whether the treatment works.

Participants

About 28 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jan 2025

Expected to finish

Jan 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 80 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Supratentorial ischemic stroke diagnosed by neuroimaging and clinical analysis; * Clinically stable (stable vital signs for 24 hours; no chest pain in the last 24 hours; no significant arrhythmia; no evidence of deep vein thrombosis); * Normal or corrected-to-normal vision; * No previous experience with HD-tDCS; * Ability to provide informed consent (patient or legal representative); * Ability to comply with the intervention and assessment schedule of the protocol. * Presence of visual verticality misperception. Exclusion Criteria: * Migraine; * Pregnancy; * Pacemakers; * Seizures; * Claustrophobia; * Transient ischemic attack; * Other neurological disorders; * Psychiatric disorders; * Sensitive scalp or prior brain surgery; * Diagnosis of severe carotid atherosclerotic disease (stenosis ≥ 70%); * Presence of metal implants, cardiac pacemakers, or claustrophobia; * Diagnosis of COVID-19 or other infectious disease that requires isolation; * Uncontrolled medical problems, such as terminal cancer or kidney disease. * Left-handed or mixed-handed individuals as determined using the Edinburgh Handedness Inventory (Appendix 10); * Peripheral vestibular deficits observed using neuro-otological screening tests when the participant's clinical condition allows (head shake test, head thrust test, Dix-Hallpike, and Pagnini-McClure); * Prior musculoskeletal disorders affecting alignment and postural balance (e.g., moderate to severe scoliosis; torticollis); * Cognitive dysfunction outside normal limits on the Mini-Mental State Examination (score below 23); * Global or Wernicke's aphasia;

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Conditions

The condition(s) this trial relates to.

ischemic stroke stroke disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Stroke

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    2 sites. The list below names each one and where it is.

  2. The official record

    The full official record for this study. This one lists no contact details, but it is the first place any would appear.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Ribeirão Preto Medical School, University of São Paulo

    Ribeirão Preto, São Paulo, 14015160, Brazil

  • University of São Paulo, Ribeirão Preto Medical School

    Ribeirão Preto, São Paulo, 14049-900, Brazil

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