New hope for teens with chronic migraine?

NCT ID NCT04616326

Ongoing Disease control Sponsor: Eli Lilly and Company Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether galcanezumab, a monthly injection, can prevent chronic migraine in 312 adolescents aged 12 to 17. Participants receive either the drug or a placebo for 3 months. The main goal is to see if the drug reduces the number of migraine days per month.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: galcanezumab
What this could lead to: If it works, this could give teens with chronic migraine a new preventive option to reduce headache days.
What could go wrong: This is a single phase 3 trial; results may not confirm benefit. Side effects or lack of efficacy are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Headache migraine disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CHRONIC MIGRAINE

Contacts and locations

Locations

21st Century Neurology, a Division of Xenoscience, Inc.

Phoenix, Arizona, 85004, United States
Access Clinical Trials - Nashville

Nashville, Tennessee, 37203, United States
Allied Biomedical Research Institute

Miami, Florida, 33155, United States
Apollo Hospitals Ahmedabad

Ahmedabad, 382428, India
Artemis hospital

Gurugram, 122003, India
Ascension Via Christi Research

Wichita, Kansas, 67214, United States
Assistance Publique Hôpitaux de Marseille - Hôpital de la Timone

Marseille, 13385, France
Atmaram Child Care

Kanpur, 208011, India
Avanza Medical Research Center

Pensacola, Florida, 32503, United States
Bio-Medical Research LLC

Miami, Florida, 33144, United States
Bordeaux University Hospital - Pellegrin

Bordeaux, 33076, France
CHU d'Amiens-Picardie - Hôpital Sud

Amiens, 80054, France
Center for Neurosciences

Tucson, Arizona, 85718, United States
Central India Cardiology and Research Institute

Nagpur, 440015, India
Centre Hospitalier Intercommunal de Créteil

Créteil, 94010, France
Centre Hospitalier Régional Universitaire de Lille - Hôpital Roger Salengro

Lille, 59037, France
Centro de Investigacion Medica Aguascalientes (CIMA)

Aguascalientes, 20116, Mexico
Children Mercy Pediatric Clinical Research Unit

Kansas City, Missouri, 64108, United States
Children's Hospital Colorado

Aurora, Colorado, 80045, United States
Cincinnati Children's Hospital Medical Center

Cincinnati, Ohio, 45229, United States
Clinica De Enfermedades Cronicas y Procedimientos Especiales

Morelia, 58249, Mexico
Clinical Neuroscience Solutions, Inc. dba CNS Healthcare

Jacksonville, Florida, 32256, United States
Coastal Pediatric Research

Charleston, South Carolina, 29414, United States
Cohen Children's Northwell Health Physician Partners - Pediatric Neurology

New Hyde Park, New York, 11042, United States
D&H Tamarac Research Center

Tamarac, Florida, 33321, United States
Dent Neurologic Institute

Amherst, New York, 14226, United States
Department of Pediatrics

Nagpur, 441108, India
EMDA Clinical Research

Miami, Florida, 33126, United States
Ezy Medical Research

Miami Lakes, Florida, 33015, United States
G.B. Pant Institute of Postgraduate Medical Education & Research

New Delhi, 110002, India
Getwell Hospital and Research Institute

Nagpur, 440012, India
Headache Center of Hope

Cincinnati, Ohio, 45236, United States
Herlev and Gentofte Hospital

Copenhagen, 2730, Denmark
Hospital Civil Fray Antonio Alcalde

Guadalajara, 44280, Mexico
Hospital Clinico de Valencia

Valencia, 46010, Spain
Hospital Clínico Universitario de Valladolid

Valladolid, 47005, Spain
Hospital Infantil de Mexico Federico Gomez

Mexico City, 6720, Mexico
Hospital Universitari Vall d'Hebron

Barcelona, Spain
Hospital Universitario Virgen Del Rocio

Seville, 41013, Spain
Hospital de la Santa Creu i Sant Pau

Barcelona, 8041, Spain
Hôpital Armand Trousseau

Paris, 75571, France
IRCCS Istituto Neurologico Carlo Besta

Milan, 20133, Italy
Infinity Life Research Group

Tamarac, Florida, 33321, United States
Isala, locatie Zwolle

Zwolle, 8025 AB, Netherlands
Konan Hospital

Kobe, 658-0064, Japan
Mangala Hospital & Mangala Kidney Foundation

Mangalore, 575003, India
MedVadis Research Corporation

Waltham, Massachusetts, 02451, United States
Medical Research Partners

Ammon, Idaho, 83406, United States
Medical Research Partners - Logan

Logan, Utah, 84341, United States
Medipoint Hospitals Pvt. Ltd.

Pune, 411007, India
Miller Children's & Women's Hospital Long Beach

Long Beach, California, 90806, United States
Minneapolis Clinic of Neurology - Burnsville Office

Burnsville, Minnesota, 55337, United States
Neuroscience

Roma, 165, Italy
Northwest Clinical Research Center

Bellevue, Washington, 98007, United States
Northwest Clinical Trials

Boise, Idaho, 83704, United States
Northwest Florida Clinical Research Group

Gulf Breeze, Florida, 32561, United States
Operadora Unidad de Investigación en Salud de Chihuahua S.A. de C.V.

Chihuahua City, 31203, Mexico
Palm Beach Research Center

West Palm Beach, Florida, 33409, United States
PanAmerican Clinical Research - Guadalajara

Guadalajara, 44670, Mexico
Pharmasite Research, Inc.

Baltimore, Maryland, 21208, United States
Phoenix Children's Hospital

Phoenix, Arizona, 85016, United States
Policlinico Umberto I

Roma, 161, Italy
Ponce Medical School Foundation Inc.

Ponce, 00716, Puerto Rico
Praxis Dr. Astrid Gendolla

Essen, 45133, Germany
Precise Research Centers

Flowood, Mississippi, 39232, United States
Prime Clinical Research - Lewisville

Lewisville, Texas, 75067, United States
Proven Endpoints

Ridgeland, Mississippi, 39157, United States
Providence Health & Services

Portland, Oregon, 97225, United States
Rehabilitation & Neurological Services

Huntsville, Alabama, 35805, United States
Saint Peter's University Hospital

New Brunswick, New Jersey, 08901, United States
Sanos Clinic - Nordjylland

Aalborg, 9362, Denmark
Seattle Children's Hospital

Seattle, Washington, 98105, United States
Sir Ganga Ram Hospital

New Delhi, 110060, India
St. Alexius Medical Center

Hoffman Estates, Illinois, 60169, United States
Tanaka Neurosurgery&Headache Clinic

Kagoshima, 892-0844, Japan
Tatsuoka Neurology Clinic

Kyoto, 600-8811, Japan
Tokyo Headache Clinic

Tokyo, 151-0051, Japan
Tokyo Medical University Hospital

Shinjuku-ku, 160-0023, Japan
Tominaga Hospital

Osaka, 556-0017, Japan
UPMC Children's Hospital of Pittsburgh

Pittsburgh, Pennsylvania, 15224, United States
USF Health

Tampa, Florida, 33612, United States
UT Southwestern Medical Center

Dallas, Texas, 75235, United States
Umenotsuji Clinic

Kochi, 780-8011, Japan
University of Kentucky Chandler Medical Center

Lexington, Kentucky, 40536, United States
Velocity Clinical Research at Raleigh Neurology

Raleigh, North Carolina, 27607, United States
Vitaly Clinical Research

Miami, Florida, 33125, United States
Wellness Clinical Research

Miami Lakes, Florida, 33016, United States
Yamaguchi Clinic

Nishinomiya, 663-8204, Japan

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