Could a common cholesterol drug stop chronic migraine?

NCT ID NCT06485336

Recruiting now Disease control Sponsor: St. Olavs Hospital Source: ClinicalTrials.gov ↗

First seen Jul 20, 2026 · Last updated Jul 21, 2026 · Updated 1 time

Summary

This study tests whether taking atorvastatin (a widely used cholesterol-lowering drug) every day for 12 weeks can reduce the number of migraine days in people with chronic migraine. About 300 adults aged 18–64 with chronic migraine will receive either atorvastatin or a placebo pill. The goal is to see if the drug prevents attacks better than placebo, with fewer side effects, and at a lower cost than current treatments.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: atorvastatin 40 mg tablet taken daily for 84 days
What this could lead to: If it works, this could offer a new, affordable, and well-tolerated daily pill to prevent chronic migraine attacks.
What could go wrong: This is a Phase 2 trial, so results are not yet confirmed. Previous smaller studies showed promise, but the larger study may not replicate those benefits, and side effects are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

migraine disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CHRONIC MIGRAINE

Contacts and locations

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Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••
Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

Haukeland University Hospital
RECRUITING

Bergen, Norway

Contact Email: •••••@•••••
Oslo University Hospital, Rikshospitalet
NOT_YET_RECRUITING

Oslo, Norway

Contact Email: •••••@•••••
Oslo University Hospital, Ullevål
NOT_YET_RECRUITING

Oslo, Norway

Contact Email: •••••@•••••
St. Olavs hospital
RECRUITING

Trondheim, Norway

Contact Phone: •••-•••-•••• Email: •••••@•••••

Contact Email: •••••@•••••
University Hospital Northern Norway
RECRUITING

Tromsø, Norway

Contact Email: •••••@•••••
University Hospital, Akershus
NOT_YET_RECRUITING

Lørenskog, Norway

Contact Email: •••••@•••••

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