CHRONIC MIGRAINE

This study aims to find the most effective way to prevent migraines in children and teens using telehealth. Researchers will compare cognitive behavioral therapy (CBT) delivered via video calls alone versus CBT combined with the medication amitriptyline. The trial involves 400 yo…

This study is testing whether injections of an experimental drug called IPN10200 can help prevent migraine attacks in adults. The drug works by blocking chemical messengers in the brain that cause migraine pain. Researchers will give 641 participants with either episodic or chron…

This study is testing whether a daily pill called atogepant can help prevent chronic migraines in teenagers aged 12 to 17. About 420 teens worldwide will take either the real medicine or a placebo (sugar pill) for 12 weeks, and neither they nor their doctors will know which one t…

This study aims to learn if a ketogenic diet (a high-fat, low-carb diet) is a safe and effective treatment for children with hard-to-treat conditions like epilepsy, autism, migraines, or brain tumors. Researchers will follow 100 children under 18 who are already on this diet to s…

This study is monitoring the safety and real-world effectiveness of atogepant, an already-approved oral medication for preventing migraines. It will follow 3,000 Korean adults with chronic or episodic migraines who are prescribed the drug by their doctors as part of their normal …

This study is testing whether Xeomin injections in the head and neck muscles can help prevent chronic migraine. About 780 people with frequent migraines will receive either the real injections or a placebo over a year. The main goal is to see if Xeomin reduces the number of migra…

This study aims to see how well and how safely the medication rimegepant works to prevent migraines in everyday life. It will follow 100 people with frequent migraines for two years as they take the medication every other day. Researchers will track how many migraine days they ha…

This study is testing if adding laser acupuncture to standard migraine medication helps people who aren't getting enough relief from drugs alone. Sixty adults with chronic migraines will receive either real or fake (sham) laser treatments to see if the real therapy reduces the nu…

This study is testing how well and how safely a medication called rimegepant works to treat migraine attacks as they happen. It will enroll 100 people with migraines to take a dissolving tablet when a migraine starts and track their pain and symptoms over several hours. The main …

This study is testing whether gentle, non-invasive brain stimulation can reduce migraine pain and headache frequency. Researchers will compare two types of stimulation (one-sided and both-sided) against a fake treatment in 60 people with chronic migraines. The goal is to see if t…

This study is testing a new lifestyle and behavior program to help manage chronic migraine. Researchers will enroll 60 adults who have had chronic migraine for at least a year to see if the program is practical and acceptable. The main goals are to check if people can stick with …

This study is testing a small, implanted device that sends gentle electrical pulses to nerves in the head to reduce migraine frequency. It is for adults with chronic or frequent migraines who have not gotten enough relief from at least three different preventive medications. The …

This study is testing whether a type of behavioral therapy called Acceptance and Commitment Therapy (ACT) can help reduce the life disruption caused by chronic migraine. Researchers will compare adding 8 virtual ACT classes to standard headache treatment against standard treatmen…

This study is testing a mind-body skills program delivered by nurses to help children and teens (ages 10-17) with migraines reduce their headache days. Researchers are comparing different versions of the program to find the most effective combination of coaching sessions, home pr…

This study aims to understand how daily pain, mood, and activities are connected by having 800 participants use a smartphone app called SOMA for four months. The goal is to find patterns that might predict when short-term (acute) pain becomes long-term (chronic) pain. A smaller g…