CHRONIC MIGRAINE

This phase 3 trial tests whether Xeomin (a botulinum toxin type A injection) can reduce the number of migraine days in people with chronic migraine. About 780 participants will receive either Xeomin or a placebo injected into head and neck muscles every 12 weeks for up to 55 week…

This study is testing whether the drug rimegepant, taken as a tablet every other day, can help prevent migraines in adults who have at least four migraine days per month. Researchers will track changes in migraine frequency over three to twelve months. The goal is to see if rimeg…

This study will follow 2,641 people with episodic or chronic migraine to see how well newer drugs—like monoclonal antibodies, gepants, ditans, and a sumatriptan-naproxen combo—work in everyday life. Researchers will track monthly migraine days, pain relief within 2 hours, and any…

This study tests whether the drug atogepant (Qulipta) can safely prevent chronic migraines in teenagers aged 12 to 17. About 420 teens with chronic migraine will take either atogepant or a placebo pill daily for 12 weeks. Researchers will track side effects and changes in monthly…

This study tests whether CBD oil (a non-psychoactive cannabis compound) can prevent chronic migraines. About 72 adults with frequent migraines will receive either a low dose of CBD, a higher dose, or a placebo for several months. Researchers will track changes in headache days to…

This study looks at the safety and effectiveness of atogepant, a drug already approved for migraine prevention, in Korean adults. About 3000 people with chronic or episodic migraines will take the drug as prescribed by their doctor and be followed for up to 12 weeks. The goal is …

This study tests a new medication called IPN10200, given as injections into the head and neck muscles, to prevent migraines in adults. About 641 people with episodic or chronic migraine will receive either the drug or a placebo. The goal is to see if it safely reduces the number …

This study tests whether adding a daily pill (amitriptyline) to online cognitive behavioral therapy (CBT) helps prevent migraines in children better than online therapy alone. About 400 kids with frequent migraines will be followed for months to see if headache days drop by half …

This study is testing a nurse-led mind-body program to help children and teens with migraine have fewer headache days. The program combines different treatment parts, like relaxation and coping skills, to find the best mix. The study will include 260 participants aged 10-17 who h…

This pilot study from Mayo Clinic tests whether a virtual lifestyle behavior training program can help people with chronic migraine have fewer attacks. Sixty adults with chronic migraine for at least one year will be randomly assigned to either the lifestyle program or a sham edu…

This study tests if a lidocaine infusion into blood vessels in the skull can reduce chronic migraine pain, frequency, and duration. It involves 40 adults aged 18-75 with severe, hard-to-treat migraines. The treatment numbs pain receptors to provide relief.

This small study tests whether placing a cotton ball soaked in lidocaine (a numbing medicine) inside each nostril for 5 minutes before Botox injections reduces pain. 18 adults with chronic migraine who get regular Botox shots will receive both lidocaine and saline (salt water) on…

This pilot study tests whether Well-Being Therapy, a short psychotherapy focused on building positive mental health, can reduce disability and distress in 30 adults with chronic migraine. Participants will receive either the therapy or a control condition. The goal is to see if t…

This study tests a device called the PRIMUS System that uses mild electrical pulses to stimulate nerves in the head and neck. It is for people with chronic or frequent migraine who have not gotten relief from at least three preventive medicines. The goal is to see if the device s…

This study tests if a gentle, non-invasive brain stimulation (tDCS) given for 20 minutes daily over 20 days can reduce migraine pain. About 60 people with chronic migraine will receive either real or sham stimulation, and 20 people with episodic migraine will be observed for comp…

This study is testing how well and how safely the drug rimegepant works for treating migraine attacks as they happen. Researchers will follow 100 people with migraine (with or without aura, or chronic migraine) who take a 75 mg rimegepant tablet when they have an attack. The main…

This study tests if adding laser acupuncture to standard care can reduce migraine days and medication use in people with chronic migraine who don't get enough relief from drugs. About 60 adults will receive either real or sham laser acupuncture over several months. Researchers wi…

This study tests whether Acceptance and Commitment Therapy (ACT), a type of behavioral training, can improve daily functioning in adults with chronic migraine. Forty participants will either receive ACT plus their usual care or just usual care alone. Over a year, they will fill o…

This study aims to find out which patient factors influence how well a nerve block works for medication-overuse headache. Researchers will give 70 adults an ultrasound-guided injection and track their pain and medication use for one month. The goal is to better predict who will b…

This study uses a smartphone app called SOMA to track daily mood, pain, and activity in 800 people with acute or chronic pain over four months. The goal is to find patterns that predict whether acute pain becomes chronic, or if chronic pain flares up. A smaller group will also ha…

This study follows 100 children under 18 who are already on a ketogenic diet for conditions like drug-resistant epilepsy, autism, chronic migraine, or brain tumors. Researchers want to see if the diet supports healthy growth, improves symptoms, and boosts quality of life. The die…