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Online therapy plus pill may cut Kids' migraines in half

NCT ID NCT05889624

Recruiting now Prevention Sponsor: Children's Hospital Medical Center, Cincinnati Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 11, 2026 · Updated 2 times

Summary

This study tests whether adding a daily pill (amitriptyline) to online cognitive behavioral therapy (CBT) helps prevent migraines in children better than online therapy alone. About 400 kids with frequent migraines will be followed for months to see if headache days drop by half and daily life improves. The goal is to find the best first-line treatment that is easy to access from home.

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Conditions

The condition(s) this trial relates to.

Headache headache disorder migraine disorder migraine with aura migraine without aura

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CHRONIC MIGRAINE HEADACHE HEADACHE DISORDERS HEADACHE, MIGRAINE MIGRAINE MIGRAINE DISORDERS MIGRAINE WITH AURA MIGRAINE WITHOUT AURA

Contacts and locations

Locations

  • Children's Hospital of Philadelphia

    RECRUITING

    Philadelphia, Pennsylvania, 19104, United States

  • Cincinnati Children's Hospital Medical Center

    RECRUITING

    Cincinnati, Ohio, 45229, United States

    Contact Email: •••••@•••••

  • Clinical Integrative Research Center of Atlanta, Inc

    RECRUITING

    Atlanta, Georgia, 30328, United States

  • Dell Children's Hospital-UT Health

    RECRUITING

    Austin, Texas, 78712, United States

  • Dent Neurological Institute

    RECRUITING

    Amherst, New York, 14226, United States

  • Louisiana State Univ/Children's Hospital of New Orleans

    RECRUITING

    New Orleans, Louisiana, 70118-5720, United States

  • Marshall Health

    RECRUITING

    Huntington, West Virginia, 25701, United States

  • Nationwide Childrens

    RECRUITING

    Columbus, Ohio, 43205, United States

  • Nemours Children's Health System

    RECRUITING

    Wilmington, Delaware, 19810, United States

  • Norton Children's Neuroscience Institute/ UofL School of Medicine

    RECRUITING

    Louisville, Kentucky, 40292, United States

  • Phoenix Children's Hospital - Barrow Neurological Institute

    RECRUITING

    Phoenix, Arizona, 85016-7710, United States

  • University of Alabama at Birmingham Children's of Alabama

    RECRUITING

    Birmingham, Alabama, 35233, United States

  • University of California San Francisco

    RECRUITING

    San Francisco, California, 94115, United States

  • University of Colorado/Children's Hospital Colorado

    RECRUITING

    Aurora, Colorado, 80045, United States

  • University of Tennessee Health Science Center/ LeBonheur Children's Hospital

    RECRUITING

    Memphis, Tennessee, 38103, United States

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