Headache disorder

This phase 3 trial is testing atogepant, a daily pill already approved for adults, to prevent episodic migraines in children aged 6 to 17. About 450 participants will receive either a low or high dose of the drug or a placebo for 12 weeks. The goal is to see if it safely reduces …

This study tests whether rimegepant, a dissolving tablet, can prevent migraines in children and adolescents ages 6 to under 18. About 640 participants will receive either the drug or a placebo for 12 weeks. The main goal is to see if the drug reduces the number of migraine days p…

This study tests an implanted device that stimulates nerves at the back of the head to prevent chronic cluster headaches. Ten adults with difficult-to-treat cluster headaches will receive the implant and use it daily for 48 weeks. Researchers will track side effects and whether t…

This study tests whether the drug ubrogepant can prevent menstrual migraines when taken daily for a week around each period. About 496 women with regular cycles and a history of menstrual migraines will receive either ubrogepant or a placebo for three cycles, then all may receive…

This study compares three oral medications used to prevent migraines: atogepant (a newer drug), topiramate, and propranolol (both older). About 1,335 adults with migraine will be randomly assigned to one of the three drugs for 12 weeks. Researchers will track headache frequency a…

This pilot study explores whether taking high-dose cocoa extract supplements is feasible and acceptable for people with episodic migraine. Researchers will compare two doses of cocoa extract to a placebo, tracking how many participants stick with the daily pills for 12 weeks. The…

This phase 3 trial tests whether Xeomin (a botulinum toxin type A injection) can reduce the number of migraine days in people with chronic migraine. About 780 participants will receive either Xeomin or a placebo injected into head and neck muscles every 12 weeks for up to 55 week…

This study tests whether eptinezumab, given as an IV infusion, can reduce the number of migraine days in adolescents aged 12 to 17 who have chronic migraine (15 or more headache days per month). Participants will receive either the drug or a placebo (salt water) and track their h…

This study tests the long-term safety of eptinezumab (Vyepti) in 600 children and teens aged 6 to 17 with chronic or episodic migraine. Participants must have completed a prior study. The main goal is to track side effects over time, with additional measures of drug levels and im…

This Phase 3 study tests whether taking rimegepant (a dissolving tablet) for 7 days around each period can prevent menstrual migraines in women aged 18-45. About 723 women with regular cycles and a history of menstrual migraines will receive either rimegepant or a placebo. The go…

This study tests whether eptinezumab, given through a vein, can safely reduce the number of migraine days in children and teens aged 6 to 17 with episodic migraine. Participants receive either the drug or a placebo, and researchers track monthly migraine days over 12 weeks. The g…

This study is testing whether the drug rimegepant, taken as a tablet every other day, can help prevent migraines in adults who have at least four migraine days per month. Researchers will track changes in migraine frequency over three to twelve months. The goal is to see if rimeg…

This study will follow 2,641 people with episodic or chronic migraine to see how well newer drugs—like monoclonal antibodies, gepants, ditans, and a sumatriptan-naproxen combo—work in everyday life. Researchers will track monthly migraine days, pain relief within 2 hours, and any…

This study tests whether blocking a small artery in the brain (the middle meningeal artery) with a special glue can prevent chronic migraines. About 70 adults with hard-to-treat chronic migraine will receive the procedure. The main goal is to see if it safely reduces the number o…

This study tests whether the drug atogepant (Qulipta) can safely prevent chronic migraines in teenagers aged 12 to 17. About 420 teens with chronic migraine will take either atogepant or a placebo pill daily for 12 weeks. Researchers will track side effects and changes in monthly…

This Phase 2 trial tests whether a new drug called MEDI0618 can safely reduce the number of migraine headache days in adults with episodic migraine. About 488 participants will receive either the drug or a placebo as a shot under the skin. The main goal is to see if the drug lowe…

This study tests whether CBD oil (a non-psychoactive cannabis compound) can prevent chronic migraines. About 72 adults with frequent migraines will receive either a low dose of CBD, a higher dose, or a placebo for several months. Researchers will track changes in headache days to…

This small study tests an implanted device that sends mild electrical pulses to nerves in the head and neck to prevent chronic cluster headaches. Ten adults who did not get better with the drug verapamil will receive the stimulator. Researchers will check how safe it is and wheth…

This study is for people with idiopathic intracranial hypertension (IIH) who have been on the drug acetazolamide for over a year without enough relief. It tests whether placing a small stent in a narrowed brain vein can lower the pressure and improve symptoms like headache and vi…

This study tests whether atorvastatin, a common cholesterol medicine, can prevent migraine attacks in adults with episodic migraine (4-14 attacks per month). Researchers will compare a 20mg dose, a 40mg dose, and a placebo over several months. The goal is to see if the drug reduc…

This study tests whether placing a small tube (stent) in a narrowed brain vein works better than standard medication for people with idiopathic intracranial hypertension (high pressure in the brain). About 74 adults with this condition and a narrowed vein will be randomly assigne…

This study tests a procedure called transvenous embolization to treat spontaneous intracranial hypotension, a condition where spinal fluid leaks cause severe headaches. Researchers at Mayo Clinic will enroll 200 people with confirmed CSF-venous fistulas. The goal is to see if blo…

This study tests whether repeated injections of a steroid around a nerve in the back of the head can prevent cluster headache attacks in people with chronic cluster headache. Fifty adults with at least four attacks per week will receive either the steroid or a placebo injection e…

This phase 2 trial tests whether a weekly dose of cabergoline, a drug that affects dopamine, can reduce the number of migraine days in adults with episodic migraine (4-14 migraine days per month). 150 participants will be randomly assigned to receive cabergoline (0.5 mg or 1.0 mg…

This study tests whether placing a small stent in a narrowed brain vein can reduce high pressure inside the skull and improve symptoms like vision loss, headache, and tinnitus. About 114 adults with newly diagnosed idiopathic intracranial hypertension will be randomly assigned to…

This observational study will follow 700 people with migraine who are prescribed anti-CGRP drugs (monoclonal antibodies or gepants) for prevention. Over two years, researchers will track changes in monthly headache days, migraine impact, and disability. The goal is to see how the…

This study compares two types of CT myelography scans to detect CSF-venous fistulas, abnormal connections that cause spinal fluid leaks, in 200 adults with spontaneous intracranial hypotension (low-pressure headaches). Participants will be randomly assigned to receive either a ne…

This study tests a simple 10-question scale designed to help neurologists quickly identify migraine patients who could benefit from physiotherapy. Many migraine patients have neck problems that make their headaches worse, but neurologists often lack time or training to assess thi…

This study aims to create an objective way to diagnose and monitor light sensitivity by measuring facial features, pupil reactions, and nerve responses to light. Researchers will compare 120 people with and without light sensitivity (due to traumatic brain injury or migraine) to …

This Phase 2 study tests whether a daily pill called EVO756 can prevent migraines in adults who have not had success with other preventive treatments. About 330 participants will receive either EVO756 or a placebo, and researchers will track how many migraine days they have each …

This phase 3 trial tests whether injections of Xeomin (a botulinum toxin type A) into head and neck muscles can prevent episodic migraines. About 990 adults with episodic migraine will receive either Xeomin or a placebo every 12 weeks for up to 55 weeks. The main goal is to see i…

This study looks at the safety and effectiveness of atogepant, a drug already approved for migraine prevention, in Korean adults. About 3000 people with chronic or episodic migraines will take the drug as prescribed by their doctor and be followed for up to 12 weeks. The goal is …

This study tests whether the medicine rimegepant can prevent migraines in teenagers aged 12 to 17 who have frequent, long-lasting headaches. About 200 teens will take either rimegepant or a placebo every other day for 3 months, then all will receive rimegepant for a year. The goa…

This study tests a new medication called IPN10200, given as injections into the head and neck muscles, to prevent migraines in adults. About 641 people with episodic or chronic migraine will receive either the drug or a placebo. The goal is to see if it safely reduces the number …

This study tests whether adding a daily pill (amitriptyline) to online cognitive behavioral therapy (CBT) helps prevent migraines in children better than online therapy alone. About 400 kids with frequent migraines will be followed for months to see if headache days drop by half …

This study tests a small device placed inside the nose that delivers gentle stimulation to prevent migraines. 110 adults with migraines will use the device at home every other day for six weeks. Researchers will track how many migraine days they have compared to a group that star…

This study tests a new drug, elismetrep, to see if it can quickly stop migraine pain and bothersome symptoms like nausea or light sensitivity. About 1800 adults with frequent migraines will receive either the drug or a placebo. The main goal is to measure how many people are pain…

This study tests the long-term safety of rimegepant, a migraine medication taken as a dissolving tablet, in children and adolescents aged 6 to 18. About 600 participants with a history of migraine will take the drug as needed for up to one year. The main goal is to check for side…

This study looks at whether taking a second dose of the migraine medication rimegepant is safe and helpful for adults whose migraine pain isn't fully relieved by the first dose. About 400 people aged 18 and older with a history of migraines will take part. Researchers will track …

This study looks at whether the position of a neck muscle before dry needling changes how well the treatment works for chronic neck pain. About 80 adults with neck pain lasting over 3 months will be randomly assigned to have the muscle stretched or shortened during two needling s…

This study tests whether rimegepant, a fast-dissolving tablet, can safely relieve migraine pain in children and adolescents aged 6 to 18. About 2,100 participants will receive either the drug or a placebo during a migraine attack. The main goal is to see if more kids become pain-…

This study tests whether doing yoga-based exercises once a week for 8-12 weeks can reduce headache frequency and improve sleep and quality of life in people with chronic migraine or cluster headache. Participants can join online or in person. The goal is to see if yoga can be a h…

This pilot study will test whether chiropractic care can help people with episodic migraine (4-13 migraine days per month). Sixty adults aged 18-65 will receive either personalized chiropractic care or headache health education. The main goal is to see if a larger trial is feasib…

This pilot study tests whether a structured, evidence-based physical therapy program (including education, aerobic exercise, and relaxation) works better than standard physiotherapy for adults with migraine. About 195 participants aged 18-70 with a confirmed migraine diagnosis wi…

This study tracks about 1,000 people with migraine who are taking AJOVY (fremanezumab) as part of their regular care. The goal is to see how safe the drug is over the long term, especially regarding heart problems. Researchers will also collect information on how well it works. T…

This study tests whether a combination of two existing drugs, nortriptyline and topiramate, can reduce vertigo and other symptoms in people with Meniere's disease. Forty adults with active Meniere's will take the drugs or a placebo for 8 weeks. The goal is to see if this approach…

This study is testing whether open-label placebo pills—capsules with no active ingredients that patients know are fake—can reduce chronic pain and improve sleep in people with temporomandibular disorder (TMD). About 111 participants will be split into three groups: one gets the p…

This study tests whether using a higher voltage during a nerve-blocking procedure (pulsed radiofrequency) can better relieve pain in people with chronic migraine who haven't responded to at least two preventive medications. One hundred participants will be randomly assigned to re…

This study is testing a nurse-led mind-body program to help children and teens with migraine have fewer headache days. The program combines different treatment parts, like relaxation and coping skills, to find the best mix. The study will include 260 participants aged 10-17 who h…

This study is testing a digital care program for adults with migraine. The program includes a wearable device that uses nerve stimulation, personalized exercises, and support from a care team. The goal is to see if it can reduce the number of migraine days per month. About 140 pe…

This study tests whether numbing certain scalp nerves can stop migraine pain quickly and prevent future attacks. Researchers will compare blocking two nerves versus ten nerves in 60 people who have frequent migraines. The goal is to see if this approach can eliminate headache pai…

This study tests an investigational inhaled medication called ASY202 (dihydroergotamine dry powder) for treating migraine attacks in adults. Participants use a handheld inhaler to take the drug or a placebo during separate migraine episodes, and neither they nor the study team kn…

This study compares two non-drug, virtual programs for adults with migraine. Both involve 8 weekly group sessions and online learning. Researchers want to see if these programs can reduce migraine-related disability and improve mood. Participants can continue their usual medicati…

This pilot study from Mayo Clinic tests whether a virtual lifestyle behavior training program can help people with chronic migraine have fewer attacks. Sixty adults with chronic migraine for at least one year will be randomly assigned to either the lifestyle program or a sham edu…

This study tests whether a one-time high-dose intravenous ketamine infusion can reduce the number and intensity of headaches in people with chronic daily headaches. About 56 adults will receive either ketamine or a placebo (saline) and be followed for three months. The goal is to…

This study tests an oral medication called ubrogepant, already approved for adults, to see if it safely and effectively treats migraine attacks in children and adolescents aged 6 to 17. About 1,059 participants with a history of migraine will receive either a low or high dose of …

This study tests whether a home-based virtual reality (VR) neurofeedback program is practical and helpful for adolescents aged 10-16 with migraine. Participants use a wearable EEG headband that reads brain activity and guides the VR experience during short sessions three times a …

This study tests whether a numbing nasal spray can safely reduce severe headaches after a brain aneurysm bleed. About 20 adults in the ICU will receive the spray along with standard pain meds. Researchers will compare pain levels and opioid use before and after treatment to see i…

This study tests if a lidocaine infusion into blood vessels in the skull can reduce chronic migraine pain, frequency, and duration. It involves 40 adults aged 18-75 with severe, hard-to-treat migraines. The treatment numbs pain receptors to provide relief.

This study tests whether basic body awareness therapy (gentle movement and mindfulness exercises) combined with lifestyle advice can reduce migraine attacks and improve daily life. Researchers will track pain, sleep, and quality of life in 40 adults who have at least 3 migraines …

This study tests whether Gou-Teng-San (GTS), a traditional herbal medicine, can help adults with episodic migraine. About 40 participants will be randomly assigned to receive GTS or a placebo. Researchers will measure if GTS reduces the number of migraine days per month and eases…

This study tests whether osteopathic manipulative treatment (OMT) — a gentle, hands-on therapy — can reduce muscle stiffness, improve jaw motion, and ease pain in people with chronic neck pain and headaches. Thirty adults aged 19 to 65 will receive OMT and undergo various measure…

This study looks at whether the antidepressant vortioxetine can help people who suffer from both depression and migraine. Researchers will track 31 adults over 12 weeks to see if their mood and headache symptoms improve. The goal is to find a treatment that works for both conditi…

This small study tests whether placing a cotton ball soaked in lidocaine (a numbing medicine) inside each nostril for 5 minutes before Botox injections reduces pain. 18 adults with chronic migraine who get regular Botox shots will receive both lidocaine and saline (salt water) on…

This pilot study tests whether Well-Being Therapy, a short psychotherapy focused on building positive mental health, can reduce disability and distress in 30 adults with chronic migraine. Participants will receive either the therapy or a control condition. The goal is to see if t…

This study tests if blocking the middle meningeal arteries in the brain is safe and feasible for people with hard-to-treat chronic migraines. About 13 participants will undergo the procedure and be followed for 6 months. The goal is to reduce migraine-causing substances in the br…

This study looks at whether taking a steroid pill (dexamethasone) after a nerve block in the emergency room can prevent migraines from returning within 72 hours. About 84 adults with migraines will be followed by phone or text to see if their headache comes back. The goal is to f…

This study tests whether inserting a tiny needle into the ear and applying a mild electrical current (called percutaneous needle electrolysis) can help people with frequent headaches. Researchers will use an infrared camera to measure changes in facial skin temperature, since peo…

This study looks at whether a supervised aerobic exercise program, combined with a single session of pain education, can reduce migraine-related disability and improve sensory and muscle function. One hundred women with migraine will either exercise on a treadmill three times a w…

This study tests whether injecting a long-lasting numbing medication (Exparel) into the side of the nose can reduce severe face and headache pain. About 15 adults with conditions like migraine or cluster headache will receive either the drug or a placebo, then switch groups. The …

This study tests whether a machine learning algorithm can predict the best way to deliver repetitive transcranial magnetic stimulation (rTMS) to reduce headaches and body pain in veterans with Gulf War Illness. 140 veterans will receive 13 active rTMS sessions over 3-4 months, an…

This study looks at whether a single session of ultrasound-guided dry needling—inserting thin needles into tight neck muscles—can safely reduce headache symptoms. About 50 adults who have had headaches in the last 6 months and have tender neck muscles will participate. The goal i…

This study tests a device called the PRIMUS System that uses mild electrical pulses to stimulate nerves in the head and neck. It is for people with chronic or frequent migraine who have not gotten relief from at least three preventive medicines. The goal is to see if the device s…

This early-stage study is testing a nasal spray called zavegepant in 16 children aged 6 to 12 who have had migraines for at least 6 months. The main goal is to see if the drug is safe and how the body handles it. Each child gets a single dose based on their weight, and the study …

This study tests a non-invasive device that gently stimulates a nerve in the ear to see if it can prevent headaches after a brain aneurysm procedure. About 440 adults will either get the real stimulation or a fake version. The goal is to find a safe, drug-free way to reduce pain …

This study looks at whether a supplement called MyVitalC (ESS60 in extra virgin olive oil) can improve sleep and reduce headaches. About 100 adults will track their sleep and headaches for 4 weeks without the supplement, then take it daily for 6 weeks and report any changes. The …

This small study tests a mind-body intervention for people with chronic migraines. Ten adults with frequent headaches will attend educational sessions and get personalized coaching. The goal is to see if the program is feasible and whether it can reduce migraine-related disabilit…

This study tests if a gentle, non-invasive brain stimulation (tDCS) given for 20 minutes daily over 20 days can reduce migraine pain. About 60 people with chronic migraine will receive either real or sham stimulation, and 20 people with episodic migraine will be observed for comp…

This study tests a personalized, noninvasive brain stimulation technique called TMS for people aged 18–65 with chronic symptoms after a mild concussion or traumatic brain injury. Symptoms like headache, dizziness, brain fog, and anxiety can last for months. Participants will rece…

This study tests a new way to treat severe migraines by using a mild electrical current on an artery in the head. Researchers want to see if the procedure is safe and practical for people whose headaches don't get better with standard treatments. About 12 adults with chronic migr…

This study tests a group therapy program for teens aged 13-17 with migraine. The program combines high-intensity interval training, progressive muscle relaxation, and education over 18 weeks. Researchers want to see if it reduces headache frequency, pain, and the need for medicat…

This study looks at whether surgical masks or N95 masks work better to reduce physical symptoms like headache, fatigue, and muscle pain caused by surgical smoke in operating room nurses. 38 nurses wore each type of mask for four weeks and reported their symptoms. The results show…

This study looks at whether taking ubrogepant (a migraine medication) during the earliest phase of a migraine—called the prodrome—can prevent moderate to severe headache pain. About 189 adults who already use ubrogepant will take it as usual and report their symptoms over 13 week…

This Phase 2 trial tests whether a single dose of PRT-064040 nasal spray can quickly relieve moderate to severe migraine pain and the most bothersome symptoms. About 456 adults with a history of migraines will receive either the spray or a placebo. The main goal is to see if more…

This study tests whether giving magnesium along with the standard migraine drug prochlorperazine reduces pain more than the drug alone. About 100 adults with migraines in the emergency department will receive either the combination or a placebo. Researchers will measure pain chan…

This study is testing how well and how safely the drug rimegepant works for treating migraine attacks as they happen. Researchers will follow 100 people with migraine (with or without aura, or chronic migraine) who take a 75 mg rimegepant tablet when they have an attack. The main…

This study looks at whether the migraine drug eptinezumab can stop a migraine attack while it is being given through an IV. Researchers want to know how fast the headache goes away and if other bothersome symptoms also disappear. The study will include 50 adults who have migraine…

This study compares two medicines, flunarizine and propranolol, to see which works better at reducing migraine attacks in children aged 8 to 15. The trial will enroll 44 kids who have frequent migraines and measure improvement using a special disability score. The goal is to find…

This study tests whether closing a small hole in the heart (called a PFO) can reduce migraine attacks and improve brain function. Researchers will compare 150 adults with migraines and a PFO who get the closure procedure to those who don't. The goal is to see if the procedure cut…

This study compares two types of injections for people with chronic migraines or headaches. One targets trigger points in muscles, the other blocks a nerve in the neck. The goal is to see if the simpler trigger point injection works just as well. About 1,000 adults aged 18-65 wil…

This study tests whether injecting a steroid and numbing medicine into muscle trigger points can relieve knee osteoarthritis pain as well as injecting into the knee joint itself. About 1,000 adults with knee arthritis and at least one tender muscle spot will receive either a trig…

This study looks at whether a nerve block in the back of the head can temporarily relieve severe headaches caused by a spinal fluid leak. About 34 adults with this condition will receive the injection and be monitored for pain changes. The goal is to provide a safe, accessible br…

This study tests if delivering lidocaine (a numbing medicine) and steroids directly into an artery in the scalp can safely relieve the intense headaches that follow a type of brain bleed called subarachnoid hemorrhage. The goal is to reduce pain and the need for strong opioid pai…

This study tests whether combining green light therapy with a gentle, non-invasive brain stimulation technique (tDCS) can reduce how often migraines happen and how bad they hurt. Researchers will enroll 40 adults with frequent, painful migraines. Participants will track their hea…

This study tests whether a scalp block (a numbing injection) can reduce severe headaches in patients who have had a brain aneurysm rupture. About 22 adults in intensive care will receive either standard care plus the scalp block or standard care alone. The goal is to see if the b…

This study tests whether taking rimegepant before a known trigger (like exercise, alcohol, or stress) can prevent a migraine from developing. It involves 60 adults with migraine who have reliable triggers. Participants take the medication ahead of the trigger and report if a head…

This study looks at whether Xeomin injections can reduce migraine pain and frequency in people who have had a traumatic brain injury or an unexplained health incident. About 60 adults will receive the injections and report their headache changes over 12 weeks. The goal is to see …

This study tests whether amiloride, a drug used for high blood pressure, can reduce the number of migraine aura attacks. About 40 adults with migraine with aura will take amiloride or a placebo for several weeks, then switch. The goal is to see if amiloride can prevent the visual…

This study tests if a new biodegradable heart implant can reduce migraine days better than a standard metal implant in people with a small hole in the heart (PFO). The new implant is designed to dissolve over time, potentially avoiding long-term complications like metal allergies…

This study tests a nerve block (sphenopalatine ganglion block) given through the nose to treat severe headaches after a type of brain bleed called subarachnoid hemorrhage. About 40 adults with a secured aneurysm will receive either the block plus standard pain meds or standard me…

This study tests whether a nerve block injection near the cheek can relieve severe headaches after a brain bleed (subarachnoid hemorrhage). The injection contains a numbing medicine and a steroid. The goal is to see if it reduces the need for opioid painkillers. About 195 adults …

This study tests if adding laser acupuncture to standard care can reduce migraine days and medication use in people with chronic migraine who don't get enough relief from drugs. About 60 adults will receive either real or sham laser acupuncture over several months. Researchers wi…

This early study at Mayo Clinic tests whether blocking a specific vein in the lower back (lumbar vein embolization) can safely reduce chronic headaches in people with Nutcracker physiology. Only 4 participants with daily pressure headaches that haven't responded to other treatmen…

This pilot study tests a new program called CRISP to help young adults aged 18-29 recover from concussion and manage headaches. The program focuses on support and recovery strategies. Researchers will measure how acceptable the treatment is and track changes in headache severity …

This study tests whether taking vitamin K2 supplements daily for 6 months can reduce the number of migraine days in adults with episodic migraine. Researchers will also measure if it improves artery stiffness, which is often higher in people with migraines. 160 participants will …

This study tests whether Acceptance and Commitment Therapy (ACT), a type of behavioral training, can improve daily functioning in adults with chronic migraine. Forty participants will either receive ACT plus their usual care or just usual care alone. Over a year, they will fill o…

This study tests a remote behavioral program called RELAXaHEAD for people with migraines. About 356 adults will use the app to learn skills that may reduce migraine-related disability and improve quality of life. The goal is to see if this approach works better than usual care, a…

This study tests whether repetitive transcranial magnetic stimulation (rTMS), a non-invasive brain stimulation technique, can reduce chronic headaches and improve recovery in people with mild traumatic brain injury. Researchers will compare active rTMS to a sham (fake) treatment …

This study compares two fast-dissolving migraine tablets, rimegepant (Nurtec ODT) and rizatriptan (Maxalt MLT-ODT), in adults coming to the emergency room with a migraine. The goal is to see which drug provides better pain relief within 60 and 120 minutes. 80 participants will re…

This study tests zavegepant (Zavzpret), a nasal spray already approved for migraines, in 200 adults who also take CGRP-targeting preventive medications. Researchers want to see if it provides headache relief within 2 to 4 hours and improves daily function. The goal is to find a s…

This study investigates the sequence of early warning signs, called premonitory symptoms, that occur before a migraine headache starts. Researchers will follow 500 adults with migraine who will record their symptoms using an electronic diary for up to five attacks. The goal is to…

This study is looking for ways to predict which migraine patients will respond well to a class of drugs called anti-CGRP monoclonal antibodies. Researchers will analyze clinical, biological, and brain imaging data from 350 adults with frequent migraines. The goal is to find bioma…

This study explores whether migraine attacks can be predicted before the headache phase begins. Researchers will monitor people with episodic migraine (10–14 migraine days per month) using a wearable device that tracks heart rate and other body signals, along with a diary of earl…

This study looks at how physical activity, sleep, and light exposure relate to mood in people with bipolar disorder, major depression, or no mood disorder. Over two years, participants wear activity monitors and complete smartphone diaries for up to 20 days at a time. The goal is…

This study looks at whether people with migraine have different shoulder muscle activity and arm performance compared to those without migraine. Researchers will measure muscle signals and shoulder movement in 50 adults aged 18-55. The goal is to understand how migraine might aff…

This study checks if a new melt-in-the-mouth version of a migraine drug works the same as the approved tablet. It involves 36 healthy adults who will take both forms at different times. The goal is to see if the body absorbs the drug similarly, not to treat migraines.

This study uses brain scans (fMRI) and sensory tests to explore how different types of chronic pain affect the brains of children and teens aged 10-17. Researchers hope to find shared and unique brain patterns across conditions like migraines, fibromyalgia, and abdominal pain. Th…

This study looks at why some people with chronic migraine don't get better with standard treatments. Researchers want to see if a person's level of suggestibility—how easily they respond to suggestions or expectations—might help predict who could benefit from placebo effects. The…

This study looks at 179 adults with migraine who also have neck or lower back pain. Researchers want to understand if these pains share common causes, like changes in how the brain processes pain. Participants will answer questionnaires and undergo pain assessments. The goal is t…

This study looks at how migraine headaches relate to pain sensitivity, work stress, and muscle pain in people who work at desks. Researchers will compare 159 office workers with and without migraine to find connections that could lead to better workplace health. The goal is to un…

This study aims to understand how the information given to patients about their treatment affects their response to migraine medication. Researchers will give 60 adults with chronic migraine four different treatment conditions in a random order and measure changes in headache int…

This study looks at how sleep problems and stress can trigger migraines in adults. Participants wear a WHOOP band to track sleep and body signals, and answer daily questions via a smartphone app. The goal is to find personal patterns and give tailored advice to reduce migraine at…

This study follows pregnant women with migraine who took rimegepant (Nurtec) and those who did not, to compare rates of birth defects and other pregnancy complications. About 780 participants will be tracked through 12 months after birth. The goal is to gather safety data, not to…

This observational study at Yale University is recruiting 200 people who are already taking part in another trial where they may receive a serotonergic psychedelic (like psilocybin or LSD) or a placebo. Researchers want to understand how these substances change the brain's inform…

This study looks at how daily light patterns relate to migraine headaches and sleep quality in adults. Over 8 weeks, 20 participants will track their migraines, light exposure, and sleep using diaries and devices. The goal is to understand these connections, not to test a new tre…

This online registry is studying the safety and effectiveness of the CEFALY device, a non-invasive nerve stimulator worn on the forehead, for treating migraines during and after pregnancy. Pregnant women aged 18-44 with migraines can join, regardless of whether they use the devic…

This study looks at how the way treatment information is given affects how well migraine medication works and what side effects people notice. Researchers will give 128 adults with episodic migraine six different treatments in a random order to compare drug effects, placebo effec…

This study aims to uncover genetic and biological differences between people with Menière's disease, those with vestibular migraine, and healthy individuals. Researchers will analyze blood samples from 250 participants to look for specific gene variations and biohumoral factors. …

This study aims to find out which patient factors influence how well a nerve block works for medication-overuse headache. Researchers will give 70 adults an ultrasound-guided injection and track their pain and medication use for one month. The goal is to better predict who will b…

This study tests whether adding AI-powered education to standard migraine education helps people newly diagnosed with migraine understand their condition better. 140 adults aged 18-65 will be split into two groups: one gets standard education alone, the other gets standard educat…

This study looks at why over 20% of migraine patients don't respond well to triptans, a common migraine medication. Researchers will compare tryptophan and related substances in the blood of 144 people who either respond or don't respond to triptans. The goal is to understand the…

This study is gathering information from 1,500 people with cluster headache or trigeminal neuralgia to learn more about these painful conditions. Researchers will collect surveys, genetic samples, and other health data. The goal is to better understand what causes these headaches…

This study looks at how migraine affects thinking, memory, and emotions in 150 adults. Researchers will test cognitive skills and link them to mood, anxiety, and headache patterns. The goal is to better understand the full impact of migraine on daily life.

This study is investigating why some people with migraine with aura also have a small hole in the heart called a PFO. Researchers will compare genetic differences and blood flow patterns between 240 adults who have migraine with aura, some with a PFO and some without. No new trea…

This research study collects health information from 10,000 people with brain inflammation conditions like Long COVID, ME/CFS, and autoimmune diseases. Participants use a smartphone app to share symptoms, health history, and wearable data. The goal is to find disease subtypes and…

This study is collecting information from 10,000 people aged 12 and older with common headache disorders like migraine and tension-type headaches. Researchers will track their symptoms, brain scans, genetics, and thinking abilities over time. The goal is to better understand thes…

This study aims to understand what causes Visual Snow Syndrome (VSS), a condition where people see constant flickering dots across their vision. Researchers will use brain scans and visual tests to find which brain pathways are involved. About 100 adults with VSS, migraine, or he…

This observational study tracks the safety of Ubrelvy and Qulipta, two migraine drugs, when used during pregnancy. Researchers will follow about 1,884 pregnant women with migraine in the US and Canada, comparing those who take either drug to a group who does not. The goal is to s…

This study aims to create a large database and sample bank to better understand headaches. Researchers will collect health information and treatment records from 50,000 people with headaches. The goal is to develop a system that helps doctors diagnose and treat headaches more pre…

This study looks at how thinking skills, personality, and pain sensitivity affect headache treatment in 64 adults with chronic or episodic headaches. Researchers will track participants for about six months to understand what helps or hinders treatment success. The goal is to fin…

This study looks at how immune cells and inflammatory molecules differ in people with migraine, especially those who also have autoimmune diseases like multiple sclerosis, rheumatoid arthritis, or endometriosis. Researchers will compare blood samples from 396 women to measure reg…

This study follows pregnant women with migraine who take Aimovig (erenumab-aooe) to see if the drug increases the risk of major birth defects. Researchers will compare their babies to those of women with migraine who did not take Aimovig. The goal is to gather real-world safety d…

This study uses a powerful 7T MRI scanner to look at brain structure and activity in people with migraine, visual snow, or epilepsy, as well as healthy volunteers. The goal is to better understand how these conditions affect the brain. No treatment or medication is tested—only ob…

This study uses a smartphone app called SOMA to track daily mood, pain, and activity in 800 people with acute or chronic pain over four months. The goal is to find patterns that predict whether acute pain becomes chronic, or if chronic pain flares up. A smaller group will also ha…

This large observational study will follow over 2,000 adults with migraine in Italy for two years. Researchers will collect data on symptoms, treatments, and healthcare use to better understand how migraine evolves and how patients are managed. The goal is to improve diagnosis an…

This study follows 100 children under 18 who are already on a ketogenic diet for conditions like drug-resistant epilepsy, autism, chronic migraine, or brain tumors. Researchers want to see if the diet supports healthy growth, improves symptoms, and boosts quality of life. The die…