Heart fix may stop migraines: new trial tests Hole-Closing procedure

NCT ID NCT07170176

Recruiting now Symptom relief Sponsor: First Affiliated Hospital Xi'an Jiaotong University Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether closing a small hole in the heart (called a PFO) can reduce migraine attacks and improve brain function. Researchers will compare 150 adults with migraines and a PFO who get the closure procedure to those who don't. The goal is to see if the procedure cuts monthly migraine days and eases pain.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Percutaneous patent foramen ovale closure device
What this could lead to: If it works, this could point toward a non-drug treatment for migraines in people with a common heart defect.
What could go wrong: This is a small, early-stage study with no control group for the procedure, so results may not be conclusive. The procedure itself carries risks like bleeding or device complications.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

congenital cardiovascular shunt migraine disorder patent foramen ovale

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MIGRAINE DISORDERS PATENT FORAMEN OVALE RIGHT-TO-LEFT SHUNT, CARDIAC

Contacts and locations

Locations

Luoyang Central Hospital
RECRUITING

Luoyang, Henan, 471009, China
The Second Hospital of Tianjin Medical University
RECRUITING

Tianjin, Tianjin Municipality, 300211, China

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