Melatonin may double up against childhood migraines

NCT ID NCT07743255

ENROLLING_BY_INVITATION Disease control Sponsor: Nishtar Medical University Source: ClinicalTrials.gov ↗

First seen Aug 03, 2026 · Last updated Aug 04, 2026 · Updated 1 time

Summary

This trial tests whether adding melatonin to the standard preventive drug propranolol can better reduce migraine attacks in children aged 5 to 15. Sixty children with moderate-to-severe migraine disability will receive either melatonin plus propranolol or propranolol alone for three months. Researchers will track attack frequency, pain severity, disability, and side effects to see if the combination offers extra relief.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Melatonin 3 mg at bedtime plus propranolol 1 mg/kg/day, compared with propranolol alone
What this could lead to: If adding melatonin works, it could offer a simple, well-tolerated way to reduce migraine attacks and disability in children, improving daily life.
What could go wrong: This is a small, early-stage trial, so results may not apply broadly. Melatonin may not add benefit over propranolol alone, and propranolol can cause low blood pressure or slow heart rate.

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Conditions

The condition(s) this trial relates to.

migraine disorder migraine with aura migraine without aura

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MIGRAINE DISORDERS

Contacts and locations

Locations

Nishtar Hospital Multan

Multan, Punjab Province, 66000, Pakistan

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