Migraine without aura

This study is testing whether the drug rimegepant, taken as a tablet every other day, can help prevent migraines in adults who have at least four migraine days per month. Researchers will track changes in migraine frequency over three to twelve months. The goal is to see if rimeg…

This Phase 2 study tests whether a daily pill called EVO756 can prevent migraines in adults who have not had success with other preventive treatments. About 330 participants will receive either EVO756 or a placebo, and researchers will track how many migraine days they have each …

This study tests whether adding a daily pill (amitriptyline) to online cognitive behavioral therapy (CBT) helps prevent migraines in children better than online therapy alone. About 400 kids with frequent migraines will be followed for months to see if headache days drop by half …

This study tracks about 1,000 people with migraine who are taking AJOVY (fremanezumab) as part of their regular care. The goal is to see how safe the drug is over the long term, especially regarding heart problems. Researchers will also collect information on how well it works. T…

This study is testing a nurse-led mind-body program to help children and teens with migraine have fewer headache days. The program combines different treatment parts, like relaxation and coping skills, to find the best mix. The study will include 260 participants aged 10-17 who h…

This study is testing a digital care program for adults with migraine. The program includes a wearable device that uses nerve stimulation, personalized exercises, and support from a care team. The goal is to see if it can reduce the number of migraine days per month. About 140 pe…

This study compares two non-drug, virtual programs for adults with migraine. Both involve 8 weekly group sessions and online learning. Researchers want to see if these programs can reduce migraine-related disability and improve mood. Participants can continue their usual medicati…

This study tests whether inserting a tiny needle into the ear and applying a mild electrical current (called percutaneous needle electrolysis) can help people with frequent headaches. Researchers will use an infrared camera to measure changes in facial skin temperature, since peo…

This study tests whether a machine learning algorithm can predict the best way to deliver repetitive transcranial magnetic stimulation (rTMS) to reduce headaches and body pain in veterans with Gulf War Illness. 140 veterans will receive 13 active rTMS sessions over 3-4 months, an…

This study is testing how well and how safely the drug rimegepant works for treating migraine attacks as they happen. Researchers will follow 100 people with migraine (with or without aura, or chronic migraine) who take a 75 mg rimegepant tablet when they have an attack. The main…

This study looks at whether the migraine drug eptinezumab can stop a migraine attack while it is being given through an IV. Researchers want to know how fast the headache goes away and if other bothersome symptoms also disappear. The study will include 50 adults who have migraine…

This study compares two fast-dissolving migraine tablets, rimegepant (Nurtec ODT) and rizatriptan (Maxalt MLT-ODT), in adults coming to the emergency room with a migraine. The goal is to see which drug provides better pain relief within 60 and 120 minutes. 80 participants will re…

This study is testing whether a non-invasive eye scan called optical coherence tomography (OCT) can help track neurological diseases like multiple sclerosis, Alzheimer's, Parkinson's, and migraine. Over two years, researchers will measure the thickness of retinal layers in 840 pa…

This study explores whether migraine attacks can be predicted before the headache phase begins. Researchers will monitor people with episodic migraine (10–14 migraine days per month) using a wearable device that tracks heart rate and other body signals, along with a diary of earl…

This study aims to understand how the information given to patients about their treatment affects their response to migraine medication. Researchers will give 60 adults with chronic migraine four different treatment conditions in a random order and measure changes in headache int…

This study looks at how the way treatment information is given affects how well migraine medication works and what side effects people notice. Researchers will give 128 adults with episodic migraine six different treatments in a random order to compare drug effects, placebo effec…