New migraine prevention pill EVO756 enters Mid-Stage trial

NCT ID NCT07616128

Recruiting now Prevention Sponsor: Evommune, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Aug 11, 2026 · Updated 5 times

Summary

This Phase 2 study tests whether a daily pill called EVO756 can prevent migraines in adults who have not had success with other preventive treatments. About 330 participants will receive either EVO756 or a placebo, and researchers will track how many migraine days they have each month. The goal is to see if EVO756 safely reduces migraine frequency.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: EVO756 (daily oral pill)
What this could lead to: If it works, this could offer a new daily pill to prevent migraines for people who haven't had success with other treatments.
What could go wrong: This is an early Phase 2 trial with only 330 people, so results may not hold up in larger studies. The drug may not reduce migraines better than a placebo, and side effects are still being studied.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

migraine disorder migraine with aura migraine without aura

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MIGRAINE

Contacts and locations

Show contact details

Locations

Accel Research Site-Decatur-Alcanza
RECRUITING

Decatur, Georgia, 30030, United States
Apple Medical Research Group, Inc
RECRUITING

Miami, Florida, 331216, United States

Contact Email: •••••@•••••
Asheville Neurology Specialists, Pa
RECRUITING

Asheville, North Carolina, 28806, United States
Bio Behavoural health
RECRUITING

Toms River, New Jersey, 08755, United States
CA Medical Clinic for Headache
RECRUITING

Los Angeles, California, 90067, United States
Clinical Neuroscience Solutions, Inc.
RECRUITING

Jacksonville, Florida, 32256, United States
Clinical Neuroscience Solutions, Inc.
RECRUITING

Orlando, Florida, 32819, United States

Contact Email: •••••@•••••
Clinical Trials of South Carolina
RECRUITING

Charleston, South Carolina, 29406, United States

Contact Email: •••••@•••••
Clinosis - Dent Neurologic Instite
RECRUITING

Amherst, New York, 14226, United States
Diablo Clinical Research dba Flourish Research
RECRUITING

Walnut Creek, California, 94598, United States
Eximia Research NC
RECRUITING

Raleigh, North Carolina, 27607, United States
FutureSearch Trials of Dallas
RECRUITING

Dallas, Texas, 75251, United States
FutureSearch Trials of Neurology
RECRUITING

Austin, Texas, 78731, United States

Contact Email: •••••@•••••
Michigan Headache and Neurological Institute
RECRUITING

Ann Arbor, Michigan, 48104, United States
Neuro Pain Research Center
RECRUITING

Fresno, California, 93710, United States
New England Institute for Neurology and Headache
RECRUITING

Stamford, Connecticut, 06905, United States
SFF Medical Research Group LLC
RECRUITING

Houston, Texas, 77018, United States
Trialsphere Corp
RECRUITING

Chandler, Arizona, 85286, United States

Contact Email: •••••@•••••
Vantage Clinical Trials
NOT_YET_RECRUITING

Tampa, Florida, 33614, United States
Vaught Neurological Services
RECRUITING

Crab Orchard, West Virginia, 25827, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.