Headache disorder

This study compares atogepant and topiramate, two daily pills used to prevent migraines, to see which one people tolerate better. About 545 adults with frequent migraines (at least 4 per month) will take one of the two drugs for 24 weeks, then all eligible participants will recei…

This study tested a wearable device called Nerivio that delivers mild electrical pulses to the arm to help prevent migraines. 150 people with chronic migraine used the device for 3 months. Researchers tracked changes in monthly migraine days, attack duration, and patient-reported…

This study tests whether fremanezumab, a monthly injection, can prevent episodic migraine in children aged 6 to 17. Participants receive either the drug or a placebo for 12 weeks, and researchers track changes in monthly migraine days. The goal is to see if fremanezumab is safe a…

This phase 3 trial tested whether adding the oral drug atogepant (QULIPTA) to standard Botox injections can safely and effectively prevent chronic migraine in adults. 75 participants took atogepant daily for 24 weeks alongside their regular Botox. Researchers monitored side effec…

This study looked at how well eptinezumab works and is tolerated for preventing migraines. It included 130 adults with episodic or chronic migraine. Researchers tracked changes in monthly migraine days over 3 to 12 months of treatment.

This study tested whether a daily oral medication called atogepant (brand name Qulipta) can prevent migraines in Japanese adults who have 4 to 14 migraine days per month. Over 500 participants were randomly assigned to receive one of three doses of atogepant or a placebo for 12 w…

This completed phase 4 study tested whether rimegepant, a dissolvable tablet taken every other day, can prevent migraines in adults who did not get enough relief from other oral preventive medications. Over 960 participants were enrolled. The main goal was to see if rimegepant re…

This study tested the long-term safety of a monthly injection called fremanezumab to prevent migraines in children aged 6 to 17. Over 500 participants received the shot for up to 84 months. Researchers tracked side effects, changes in migraine days, and overall safety to see if t…

This study tested whether adding eptinezumab to a brief educational program helps adults with both migraine and medication overuse headache. Over 600 participants received either eptinezumab or a placebo. The goal was to see if the drug could reduce the number of migraine days an…

This study tested whether the drug rimegepant can help prevent migraines in Chinese adults. 787 participants took either rimegepant or a placebo every other day for 12 weeks. The main goal was to see if rimegepant reduced the number of migraine days per month compared to placebo.…

This study looked at the long-term safety of eptinezumab, a drug given by IV infusion to prevent migraines. It included 160 Japanese patients who had already completed a previous study. The main goal was to see if the drug is safe and tolerable over 60 weeks of treatment.

This pilot study tested whether rimegepant (Nurtec ODT), a drug already used for migraines, could help prevent cluster headaches. Twenty adults with recurrent cluster headaches took the drug every other day for a week. Researchers measured changes in weekly attack frequency and p…

This completed Phase 4 trial tested the drug rimegepant as a preventive treatment for people with episodic migraines (4–14 migraine days per month). Over 1,400 participants were randomly assigned to take rimegepant daily, every other day, or a placebo for 12 weeks. The main goal …

This study looked at a rare type of daily headache in children and teens called NDPH. Researchers used standard headache medicines and measured certain proteins in the blood to see if they change with treatment. The goal was to better understand the condition and see how well the…

This study tested a drug called fremanezumab, given as a shot under the skin, to prevent migraines in 365 Chinese adults. Participants received either monthly or quarterly injections or a placebo for 12 weeks, followed by an open-label period. The main goal was to see if the drug…

This study tested whether the drug rimegepant, taken as a dissolving tablet every other day, could prevent migraines in Japanese adults. About 496 people with a history of migraines participated. The main goal was to see if rimegepant reduced the number of migraine days per month…

This phase 3 trial tested whether a monthly injection of erenumab could reduce the number of migraine days in adults with chronic migraine (15 or more headache days per month). Over 550 Asian participants received either the drug or a placebo for 12 weeks. The main goal was to se…

This completed phase 4 trial tested erenumab (Aimovig) in 620 adults with chronic migraine who also overused headache medication. Participants received injections of erenumab or a placebo every 4 weeks. The study measured whether erenumab could reduce medication overuse and heada…

This study tested the safety of taking rimegepant every day to prevent episodic migraines. 441 adults with a history of migraines took a daily 75mg tablet for up to 52 weeks. Researchers tracked side effects and lab changes to see if long-term daily use is safe and tolerable.

This study tested a wearable device that tracks eye movements during dizzy spells to help doctors tell apart three common inner-ear conditions: Ménière's disease, vestibular migraine, and BPPV. Four adults wore the device for 30 days to capture data. The goal was to develop a com…

This study tested whether videonystagmography (VNG) with caloric testing, a standard balance exam, can distinguish people with vestibular migraine from those with other migraines and healthy individuals. Researchers compared eye movement patterns in 173 participants across three …

This study tested whether measuring the optic nerve sheath with ultrasound can predict postdural puncture headache (PDPH) after spinal anesthesia. 176 adults having knee replacement surgery were scanned before and after the procedure. The goal was to see if changes in nerve sheat…

This clinical trial tested a new drug called Lu AG09222 to prevent migraines in 874 adults who had already tried 1 to 4 other preventive medications without success. The study compared different doses of the drug against a placebo to find the best dose. The main goal was to see i…

This study tested a drug called eptinezumab to see if it can prevent migraines in people with chronic migraine (15 or more headache days per month). About 981 adults took part, receiving either the drug or a placebo. The main goal was to see if the drug reduced the number of mont…

This study tested the long-term safety of a daily pill called atogepant for preventing migraines in adults with chronic or episodic migraine. Over 156 weeks, 596 participants took 60 mg of atogepant each day. Researchers tracked side effects and lab results to see if the drug rem…

This study looks at whether taking omega-3 supplements (fish oil) for 12 weeks can reduce migraine pain and improve quality of life in children aged 10 to 17. Half of the 58 participants will receive omega-3 oil, and the other half will receive a placebo (coconut oil). Researcher…

This study looks at how well the migraine drug ubrogepant works in everyday life for Canadian adults. About 178 participants will take the drug as prescribed and report their ability to function normally after a migraine attack. The goal is to see if ubrogepant helps people get b…

This study tested whether adding a steroid called dexamethasone to a standard occipital nerve block (using numbing medicines) provides extra headache relief. 120 adults with various headache types received injections at the back of the head. Researchers tracked changes in headach…

This study tested a web-based tool called MigraineManager for teens with migraines. The tool helps teens, their parents, and doctors track headaches and manage symptoms. The goal was to see if it could reduce how often headaches happen. 40 teens with frequent migraines took part.

This study looked at how satisfied people with migraines were using Sumavel DosePro, a needle-free injector for migraine medication. 246 adults who already used triptan drugs took part. The goal was to see if they liked this new method better than their usual treatment.

This study looked at whether adding TENS (a device that sends mild electrical pulses through the skin) and exercise to usual migraine medication can reduce pain and disability in women with migraine. Thirty-eight women participated, all continuing their prescribed meds. The goal …

This study tested a device that sends mild electrical pulses to a nerve in the ear (trigeminal nerve) to see if it helps people with migraine. 102 adults with episodic migraine received either real or sham stimulation three times a week for 12 weeks. Researchers measured headache…

This study tested how well two approved migraine medications, ubrogepant (for acute attacks) and atogepant (for prevention), work together in real-world settings. 391 adults with migraine used both drugs as prescribed by their doctor for 30 days. The goal was to see if the combin…

This study tested whether draining some fluid from the spine (a lumbar puncture) can help relieve severe headaches that often follow a brain aneurysm rupture. The trial involved 74 patients with mild to moderate brain bleeds. Half received a real lumbar puncture, and half receive…

This study looked at whether a single educational phone call from a nurse, before a doctor's appointment, could help people with medication overuse headaches. 88 adults with frequent migraines took part. The goal was to see if the call reduced the number of headache days in the m…

This study tested two drugs, zonisamide and topiramate, to see which works better for preventing migraines. About 600 people with migraines took one of the medicines for three months. Researchers measured how much their monthly migraine days dropped and how many people had at lea…

This study tested whether a nasal spray called zavegepant can safely and effectively treat migraine attacks in Asian adults. Over 1,400 participants took either the drug or a placebo when they had a moderate or severe migraine. The main goals were to see if the spray could stop p…

This study tested whether a wearable device that delivers gentle vibrations through the skull can improve balance and reduce motion sickness in people with vestibular migraine. Fifty-one participants wore the device while sitting in a rotating chair and answered questions about t…

This study looked at whether adding progressive muscle relaxation to aerobic exercise helps people with migraine more than exercise alone. 44 adults with migraine were split into two groups: one did both exercise and relaxation, the other did only exercise. Researchers measured p…

This pilot study tested a simple procedure called a sphenopalatine ganglion block (SPGB) — applying numbing medicine (lidocaine) inside the nose — against standard care (bed rest and extra fluids) for people who developed a severe headache after an accidental spinal needle punctu…

This pilot study tested whether acupuncture can help headaches in women going through IVF egg stimulation. 37 women received a 30-minute acupuncture session. Researchers measured headache intensity, stress, and emotional distress before and after treatment. The study is small and…

This study tested whether treating the greater occipital nerve on one side or both sides of the head with pulsed radiofrequency provides better migraine relief. 217 adults with episodic or chronic migraine who did not respond well to preventive medications received the procedure …

This study tested whether injecting a local anesthetic (bupivacaine) into nerves at the back of the head could reduce menstrual migraine pain. Forty-eight women with menstrual migraines received either the active drug or a placebo (salt water) twice a month for three months. The …

This study tested whether a single 2-hour infusion of ketamine combined with magnesium sulfate can reduce the number of daily attacks in people with refractory chronic cluster headache—a rare and severe headache disorder. 93 adults who had at least 2 attacks per day and did not r…

This pilot study tested whether a non-invasive vagus nerve stimulator can help people with post-COVID syndrome who suffer from fatigue and headaches. Eighteen participants used the device, and researchers measured changes in their functional status and fatigue levels. The goal is…

This study tested whether rimegepant, a dissolvable tablet, can relieve migraine pain in adults who cannot take triptans due to side effects, lack of effectiveness, or heart problems. Over 800 participants took either rimegepant or a placebo during a migraine attack. The main goa…

This completed Phase 2 trial tested whether blood thinners (rivaroxaban) or antiplatelet drugs (aspirin, clopidogrel) work better than standard migraine medication (metoprolol) for people with both migraine and a small heart hole called PFO. 1,000 participants took one of the fou…

This study tested whether inhaling isopropyl alcohol (rubbing alcohol) vapor can reduce nausea during a migraine attack, compared to inhaling eucalyptus scent. Twenty-one adults with frequent migraines took part. Participants inhaled the assigned scent at home when nausea started…

This study tested whether two combinations of migraine medications can reduce the impact of moderate-to-severe tinnitus. 78 adults were randomly assigned to receive either nortriptyline plus topiramate, verapamil plus paroxetine, or a placebo. The main goal was to see if these dr…

This study tested whether foot reflexology massage could reduce pain, improve sleep, and boost quality of life in women with migraines. Twenty-two women were split into two groups: one received 10 sessions of foot reflexology over 5 weeks, and the other served as a control. Resea…

This study looked at how well a wearable device called REN works for treating migraines in US veterans. The device uses mild electrical pulses to reduce headache pain. Researchers tracked whether veterans needed extra medication after using the device. The goal was to see if this…

This study followed 226 adults in Israel who were prescribed ubrogepant or atogepant for their migraines. Researchers wanted to see how satisfied people were with these drugs in real-world settings, not just in a lab. Participants used an app to track their experience over 90 day…

This study tested the drug erenumab in 512 adults who have frequent migraines (7 to 14 headache days per month) and had already tried at least one other preventive treatment that didn't work. The main goal was to see if erenumab could reduce the number of hours they spent with mo…

This study tested whether prazosin, a drug used for high blood pressure and PTSD nightmares, can reduce headaches in veterans and service members who had a mild traumatic brain injury. 89 participants received either prazosin or a placebo for 12 weeks. Researchers tracked headach…

This study tested whether adding virtual reality (VR) exercises to standard home balance training helps people with vestibular migraine, a condition causing dizziness and balance problems. Forty adults with the condition were split into two groups: one did only home exercises, th…

This study tested whether repeated injections of a numbing drug (bupivacaine) into the back of the head could help people with chronic migraine or chronic tension-type headache. 290 adults received either the drug or a placebo (salt water) injection over three months. The main go…

This study tested whether a type of mindfulness training called Acceptance and Commitment Therapy (ACT) could help women with frequent migraines. 75 women aged 18-65 with 4-14 migraine days per month took part. The main goal was to see if a larger study was possible, but research…

This study tested a minimally invasive procedure called pulsed radiofrequency on a nerve bundle in the face (the sphenopalatine ganglion) to see if it could reduce pain in 55 people with chronic headaches or facial pain who hadn't gotten relief from medication. The procedure uses…

This study tested two treatments for vestibulodynia, a chronic pain condition affecting the vulvar area. 209 women received either a lidocaine/estradiol cream, the antidepressant nortriptyline, both, or a placebo. The goal was to see which approach best reduces pain and improves …

This study tested a 12-week telehealth program for people with migraines, combining online modules, phone sessions, and a headache diary app. Twenty adults from a headache center in New York participated. The goal was to see if the program was feasible and acceptable, not yet to …

This study tested whether foot reflexology—a type of focused foot massage—could help people with migraines feel less pain and fatigue and have a better quality of life. 78 adults with migraines took part; half received 10 reflexology sessions over 5 weeks, while the other half co…

This study tested a procedure called pulsed radiofrequency treatment on the greater occipital nerve at the C2 level in 25 people with cervicogenic headache who had not responded to other treatments. The goal was to see if it could reduce headache severity and frequency. The treat…

This study tested a non-invasive brain stimulation technique as an add-on to standard detox therapy for people with chronic migraine and medication overuse. Researchers wanted to see if it could reduce headache days and identify who might benefit most. The trial involved 60 parti…

This study tested a nerve block called a stellate ganglion block for people with chronic migraine that didn't get better with other treatments. 42 patients received the injection under ultrasound guidance. Researchers tracked changes in monthly headache days and pain scores over …

This study tested whether combining a gentle electrical nerve stimulation device (tVNS) with stress reduction training can ease migraine. Researchers measured brain activity and inflammation in 193 adults with migraine before and after 8 weeks of treatment. The goal was to see if…

This study tested an experimental drug called BHV-2100 for quickly stopping migraine pain and related symptoms like nausea or sensitivity to light. About 647 people with migraines took either the drug or a placebo. The goal was to see if the drug could provide pain relief within …

This study looked at whether prayer can help people with migraines feel less pain and improve anxiety and depression. About 100 adults, half with migraines and half without, took part. They compared the effects of prayer versus reading a neutral text on pain sensitivity and emoti…

This study tested a personalized psychological intervention for 5 adolescents aged 12-18 with recurrent headaches. Researchers used smartphone surveys to track each teen's unique headache triggers and coping patterns, then delivered 4-5 weekly online therapy sessions based on tha…

This study tested whether adding Kinesio Taping (a special elastic tape) to posture correction exercises helps university students with tension-type headaches. Fifty-two students aged 18-25 were split into two groups: one did posture exercises alone, the other added Kinesio Tapin…

This study tested whether combining posture correction exercises with a gentle neck mobilization technique called SNAGs could reduce migraine severity, disability, and improve quality of life. Forty-four adults with episodic migraine participated. The approach is non-drug and foc…

This study tested whether adding acceptance and commitment therapy (ACT) to standard migraine treatment could reduce monthly headache days in people with high-frequency episodic migraine (9-14 headache days per month). Sixty-four adults were randomly assigned to either standard c…

This study tested whether injecting lidocaine plus platelet-rich plasma into a nerve cluster in the neck works better than lidocaine alone for chronic migraine. 200 adults with frequent migraines took part. The main goal was to see if the combo reduced monthly headache days more …

This pilot study tested a small device that stimulates nerves in the ear to help people with cyclic vomiting syndrome, a condition causing repeated bouts of severe nausea and vomiting. Forty-seven children and adults used the device either during an episode or daily for six weeks…

This study tested a device called Mi-Helper that cools the inside of the nose to treat migraine headaches at home. 156 adults with migraines used either the real device or a fake one. The goal was to see if the device could safely relieve pain and other bothersome symptoms within…

This study looked at how well the migraine medication Rimegepant works in real-world settings. Researchers followed 173 adults with migraines who took the drug as needed for acute attacks or long-term prevention. Participants recorded pain levels at several time points after dosi…

This study looked at whether giving children with migraine an IV of salt water (a common fluid) in the emergency room can help reduce their headache pain. 46 children took part. The goal was to see if the fluid alone, without any other medicine, could make them feel better.

This study tested a device that uses muscle sensors and a phone app to teach people how to relax tense muscles. It included 330 adults with chronic low back pain, recent breast surgery pain, or migraines. Half used the device plus usual care; the other half had only usual care. T…

This Phase 3 trial tested a single dose of AXS-07, a combination of meloxicam and rizatriptan, for treating migraines in adults. 302 participants took either the drug or a placebo at the first sign of migraine pain. The study measured how many were pain-free and free of their mos…

This study looked at how well and how safely lasmiditan works for treating migraine attacks. One hundred adults with migraine took lasmiditan tablets (50, 100, or 200 mg) when they had an attack. Researchers measured how many people were pain-free after 2 hours and tracked any si…

This study tested whether the drug erenumab can help prevent migraines in children (ages 6 to 12) and teenagers (ages 12 to 18) who have chronic migraines. About 284 participants received either the drug or a placebo. The main goal was to see if the drug reduced the number of mig…

This study tested whether injecting lidocaine into the GB20 acupoint (at the back of the neck) can reduce migraine attacks. Thirty adults with migraines received either weekly lidocaine injections for four weeks or daily propranolol pills. Researchers tracked headache frequency, …

This study tested whether a monthly injection of fremanezumab can prevent chronic migraines in children aged 6 to 17. About 292 participants received either the drug or a placebo. The main goal was to see if the drug reduced the number of migraine days per month over 12 weeks. Th…

This completed study tested whether repetitive transcranial magnetic stimulation (rTMS) can relieve pain, headaches, depression, and other symptoms in 204 veterans with Gulf War Illness. Participants received rTMS, a non-invasive brain stimulation, and reported changes in pain, m…

This early-stage study tested a new nasal spray called PRT-064040 in 80 healthy Chinese adults to see if it is safe and how the body processes it. Participants received either a single dose or seven daily doses of the spray or a placebo. The study does not yet test if the spray h…

This study tested a new drug called AXS-07, which combines meloxicam and rizatriptan, for treating migraine attacks in adults. The 100 participants had previously not gotten enough relief from oral CGRP inhibitors. The goal was to see if the drug could relieve headache pain and o…

This pilot study tested a new behavioral treatment called Emotional Awareness and Expression Therapy (EAET) for people with migraines. Thirty adults with frequent migraines were randomly assigned to either EAET or a control group. The therapy involved 8 weekly online sessions whe…

This study tested whether adding niacin (a B vitamin) to a standard beta blocker could help prevent migraines. 58 adults with moderate to severe migraines took either 500 mg, 1000 mg of niacin, or a placebo daily for 12 weeks. Researchers measured changes in migraine days and pai…

This early-phase study tested whether injecting lidocaine and steroids into two brain arteries could safely treat chronic migraines that don't respond to standard treatments. Ten adults with hard-to-treat migraines received one injection and were followed for 12 weeks. The main g…

This completed study looked at how well a device called Nerivio works for treating migraines in teenagers aged 12 to 18. The device is worn on the upper arm and uses mild electrical pulses to trigger the body's natural pain relief system. Researchers analyzed data from over 1,600…

This study looked at whether a non-invasive brain training method called neurofeedback can help veterans who have had a mild traumatic brain injury and still suffer from chronic headaches, trouble sleeping, and attention problems. 87 veterans were randomly assigned to receive neu…

This study tested a new wearable device that uses gentle electrical stimulation on the head and neck to relieve migraine pain. 160 people with migraines used the device during attacks, and researchers compared real stimulation to a sham (inactive) treatment. The goal was to see i…

This early-stage study looked at whether it is safe to take the experimental drug Lu AG09222 together with the approved migraine pill ubrogepant. 43 adults with migraine received both treatments or a placebo injection. The main goal was to track any side effects, not to measure h…

This completed Phase 2a trial tested whether a sublingual tablet called MTX101 can safely relieve migraine pain in adults. 78 participants took either the drug or a placebo during a migraine attack and tracked their symptoms. The study measured pain reduction and the need for res…

This study tested whether a gentle brain stimulation technique (tDCS) combined with physical therapy can reduce pain in women with chronic migraine. 80 women aged 18-50 were split into four groups to compare the treatments alone or together. The goal was to see if these non-drug …

This study tested a home-based biofeedback app called Cerebri in 279 adults with episodic migraine. Participants used the app daily for 10 minutes, along with sensors to track muscle tension, heart rate, and finger temperature. The goal was to see if this approach could reduce th…

This study tested a wearable device called Nerivio for treating migraine in 293 children aged 6 to 11. The device uses mild electrical pulses to relieve headache pain without medication. Results showed it was safe and helped many children feel better within two hours.

This completed Phase IIb trial tested an oral drug called elismetrep (K-304) in 431 adults with moderate or severe migraine. Participants received one of four doses of elismetrep or a placebo. The main goal was to see if the drug could make pain disappear within a set time. Secon…

This study looked at whether manual therapy (hands-on treatment) and a cognitive exercise therapy approach (BETY) can reduce headache pain and improve quality of life in people with temporomandibular disorder (TMD)-related headaches. 60 adults with TMD headaches were split into g…

This study looks at whether measuring the optic nerve sheath diameter—the lining around the nerve that connects the eye to the brain—using ultrasound can help doctors know if a treatment for spontaneous intracranial hypotension (a condition where low spinal fluid causes severe he…

This study follows adults with migraine who have been prescribed rimegepant (a dissolving tablet) for acute attacks. Researchers want to see how consistently the drug provides meaningful pain relief across multiple attacks and how satisfied people are with it. The study also look…

This study looked at how acupuncture affects the brain in people with migraine without aura. Forty adults received either real acupuncture or a sham (fake) version, and their brains were scanned with MRI before and after treatment. The goal was to see if real acupuncture causes d…

This study looked at nearly 2,000 people from the community to understand how depression, anxiety, and migraine are passed down through families. Researchers interviewed family members of all ages, including children as young as 8, to track patterns of these conditions over time.…

This study looked at 20 people with hard-to-treat chronic cluster headache who were already receiving occipital nerve stimulation. Researchers used brain scans to see how the stimulation changes brain activity. The goal was to understand how the treatment works, not to test if it…

This completed study aimed to find biological markers that could predict which migraine patients respond best to a new class of drugs called CGRP monoclonal antibodies. Researchers studied 243 adults with severe migraine, using genetic, brain imaging, and other tests. The goal is…

This study looked at 98 women who had a blood patch to treat severe headaches caused by an accidental spinal fluid leak during labor. Researchers wanted to see if certain factors during the blood patch procedure were linked to headaches that last 1 to 6 months. The goal is to bet…

This completed registry study followed 120 migraine patients in the Guangdong-Hong Kong-Macao Greater Bay Area who were prescribed rimegepant by their doctors. The goal was to see how the drug affects their quality of life, daily functioning, work productivity, and overall satisf…

This study looked at symptoms children experience after a migraine attack (called the postdrome phase). Researchers asked 45 children with migraine about their symptoms and how they differ by age and gender. The goal was to better understand this often-overlooked phase of migrain…

This study tested whether adding an AI-generated summary to brain MRI reports helps people understand the results. Over 2700 adults read six fictional reports and answered questions about what they found. The goal was to see if the simple summary improved understanding compared t…

This study looked at how osteopathic manual therapy (OMT) changes the brain in people with migraines, tension, or cluster headaches. Researchers used MRI scans to see if OMT affects brain structure and activity. The goal was to understand how OMT reduces pain and disability, not …

This early-stage study tested a single inhaled dose of prochlorperazine in 54 healthy adults to see if it is safe and how the body processes it. The goal was to gather information for future migraine treatments. No treatment benefit was measured, as participants were healthy volu…

This study looked at how migraine patients and healthcare providers in Thailand experience eptinezumab, a preventive migraine infusion given every 3 months. Researchers interviewed 30 participants to find out what makes it easier or harder to use this treatment in a real-world ho…

This study looked at how galcanezumab, a newer migraine prevention drug, affects the brain. Researchers used MRI scans to see if the drug changes brain structure in people with chronic migraine. The goal was to learn more about where the drug works, not to test if it helps sympto…

This study created a questionnaire to measure health beliefs in people with vestibular migraine, a condition causing dizziness and imbalance. 213 patients completed the scale and received a single educational session about their condition. The goal was to see if the scale is reli…

This small study looked at how occipital nerve stimulation (ONS) changes the way people with chronic migraine or cluster headache feel pain. Researchers used special tests and questionnaires to measure pain markers before and after ONS, and compared results to people having non-p…

This study looked at whether a 12-week walking program could change brain structure in 22 overweight adults who also had headaches. Participants either followed a diet plus walking or diet alone. Researchers measured brain gray and white matter volumes with MRI scans before and a…

This study surveyed 803 people diagnosed with New Daily Persistent Headache (NDPH) to learn about their headache patterns and what treatments they have tried. The goal was to gather information on this poorly understood condition. The survey is now complete, and the results may h…

This study surveyed 2,487 people diagnosed with cluster headache about how well their current treatments work and what they think about new treatment options. Participants filled out a single online questionnaire. The goal was to gather patient views, not to test any new drug or …

This study tested whether a small device that collects blood from the arm (instead of a needle in the vein) works as well for measuring levels of the drug zavegepant. Fourteen healthy adults took the nasal spray and gave blood samples using both methods. The goal was to see if th…

This completed study looked at survey responses from over 1,300 people with migraine in the U.S. to compare those taking rimegepant (Nurtec) with those taking triptans. Researchers examined treatment satisfaction, quality of life, work productivity, and disability. The goal was t…

This study looked at whether ivabradine, a medicine used for heart conditions, could stop migraines triggered by another drug called levcromakalim. 37 adults with migraine without aura took part. The goal was to see if ivabradine could reduce the number of migraines caused by the…

This observational study looked at 210 people with migraine or tension-type headache to see if a strong dislike of smells (osmophobia) is a reliable sign of migraine. Participants tracked their headaches and smell sensitivity for six months using diaries and questionnaires. The g…

This completed study compared 72 adults with cervicogenic headache (headache from the neck) to healthy volunteers. Researchers used questionnaires to measure central sensitization (overactive pain signaling) and neuropathic pain (nerve pain). The goal was to see if these pain mec…

This study tested whether an AI-powered voice chatbot is better than a traditional paper diary for tracking migraines in Hong Kong women. 49 women used both methods for one month each. The goal was to see which tool was more accurate, complete, and easy to use. The chatbot aims t…

This study looked at 116 adults with non-specific neck pain to understand how it relates to jaw joint problems and migraines. Researchers measured pain, disability, and quality of life using questionnaires. The goal was to uncover connections that could help design better, more p…

This study looked at whether measuring a protein called S100B in the blood can help emergency doctors tell the difference between primary headaches (like migraines) and secondary headaches (caused by something serious like a bleed or infection). Researchers enrolled 81 adults wit…

This study looked at how headaches impact sleep, pain sensitivity, and emotional well-being in 132 adults aged 18-65. Researchers measured sleep quality, central sensitization (a heightened pain state), and levels of depression, anxiety, and stress using standard questionnaires. …

This completed study tested whether a machine learning algorithm could predict the likelihood of a migraine the next day. Over 53,000 Nerivio app users aged 8 and older provided daily reports and location data. The goal was to see how accurately the model could forecast migraine …

This study surveyed 145 women with migraines who were pregnant between 2019 and 2021. It compared pregnancy and baby health between those who used the Nerivio device for migraine attacks and those who didn't. The goal was to see if using Nerivio during pregnancy is safe for both …

This completed study in 178 children aged 6-16 with migraine compared the drug propranolol to structured behavioral therapy. Researchers looked for clinical and biochemical factors that might predict who responds best to propranolol. The goal is to help personalize migraine preve…

This study looked at how common migraines are in infertile women and how they change during IVF treatment. Researchers gave 137 women a simple questionnaire to track headaches and medical history. The goal was to understand if the hormone changes from IVF can trigger or worsen mi…

This study looked at how people with brain injuries or migraines process sounds, including attention, memory, and emotions. Researchers used listening tests and brain scans (EEG, MEG, MRI) to measure responses in 262 participants. The goal was to better understand auditory defici…

This study compared neck stability, body awareness, and neck position sense in 64 people with migraine and healthy volunteers. Researchers used questionnaires and physical tests to measure differences. The goal was to better understand how migraine might affect neck function and …