Could niacin help stop migraines? new trial tests the vitamin

NCT ID NCT05846373

Completed Symptom relief Sponsor: Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested whether adding niacin (a B vitamin) to a standard beta blocker could help prevent migraines. 58 adults with moderate to severe migraines took either 500 mg, 1000 mg of niacin, or a placebo daily for 12 weeks. Researchers measured changes in migraine days and pain severity.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Niacin (nicotinic acid) extended-release tablets
What this could lead to: If it works, adding niacin to a beta blocker could reduce the number of migraine days for people with moderate to severe migraines.
What could go wrong: This is a small, early-phase trial with only 58 participants. Niacin may cause side effects like flushing, and the results may not apply to everyone with migraines.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for MIGRAINE are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

migraine disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MIGRAINE PROPHYLAXIS

Contacts and locations

Locations

BSMMU

Dhaka, 1000, Bangladesh

More trials for these conditions

Other studies related to the condition(s) this trial covers.