Could a simple nerve block ease menstrual migraines?
NCT ID NCT07576309
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tested whether injecting a local anesthetic (bupivacaine) into nerves at the back of the head could reduce menstrual migraine pain. Forty-eight women with menstrual migraines received either the active drug or a placebo (salt water) twice a month for three months. The goal was to see if the nerve block could lessen headache severity, shorten attacks, and reduce the number of painful days.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- bupivacaine
- What this could lead to
- If it works, this could offer a new, non-daily treatment option for women with menstrual migraines, reducing pain and disability during their periods.
- What could go wrong
- This is a small, completed trial with only 48 participants. The results may not apply to all migraine types, and nerve blocks carry risks like pain, bleeding, or infection at the injection site.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Saglik Bilimleri Universitesi
Istanbul, Istanbul, 34668, Turkey (Türkiye)
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Other studies related to the condition(s) this trial covers.