Daily pill could keep migraines at bay

NCT ID NCT05207865

Completed Disease control Sponsor: Pfizer Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 26, 2026 · Updated 1 time

Summary

This study tested the safety of taking rimegepant every day to prevent episodic migraines. 441 adults with a history of migraines took a daily 75mg tablet for up to 52 weeks. Researchers tracked side effects and lab changes to see if long-term daily use is safe and tolerable.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: rimegepant (a daily pill for migraine prevention)
What this could lead to: If successful, this could confirm that taking rimegepant daily is a safe option to prevent migraines, reducing attack frequency.
What could go wrong: This is a completed Phase 4 safety study, not designed to prove how well it works. Side effects or lack of long-term benefit may limit use.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

hyperacusis migraine disorder Photophobia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

EPISODIC MIGRAINE MIGRAINE PHONOPHOBIA PHOTOPHOBIA

Contacts and locations

Locations

Advanced Investigative Medicine, Inc.

Hawthorne, California, 90250, United States
Boston Clinical Trials

Boston, Massachusetts, 02131, United States
CVS HealthHUB - Runnemede

Runnemede, New Jersey, 08078, United States
CVS HealthHub - East Brunswick

East Brunswick, New Jersey, 08816, United States
CVS HealthHub - Lawrenceville

Lawrenceville, New Jersey, 08648, United States
Chase Medical Research, LLC

Waterbury, Connecticut, 06708, United States
Clinical Research Philadelphia, LLC

Philadelphia, Pennsylvania, 19114, United States
Elite Clinical Studies, LLC

Phoenix, Arizona, 85018, United States
Michigan Head Pain & Neurological Institute

Ann Arbor, Michigan, 48104, United States
OK Clinical Research, LLC

Edmond, Oklahoma, 73034, United States
Phoenix Medical Research, LLC

Miami, Florida, 33165, United States
SPRI Clinical Trials, LLC

Brooklyn, New York, 11235, United States
The Headache Clinic

Alexandria, Louisiana, 71301, United States
Tidewater Integrated Medical Research

Virginia Beach, Virginia, 23454, United States
VIP Trails

San Antonio, Texas, 78230, United States
VIP Trials

San Antonio, Texas, 78230, United States
Velocity Clinical Research

Cincinnati, Ohio, 45242, United States
Velocity Clinical Research - North Hollywood

North Hollywood, California, 91606, United States
WR-ClinSearch, LLC

Chattanooga, Tennessee, 37421, United States

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