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New migraine prevention pill shows promise in japanese trial

NCT ID NCT05399485

Completed Disease control Sponsor: Pfizer Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested whether the drug rimegepant, taken as a dissolving tablet every other day, could prevent migraines in Japanese adults. About 496 people with a history of migraines participated. The main goal was to see if rimegepant reduced the number of migraine days per month compared to a placebo.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

rimegepant (a drug taken as a dissolving tablet every other day)

What this could lead to

If successful, this could provide a new preventive option for people with migraines, reducing the number of migraine days per month.

What could go wrong

This is a completed Phase 3 trial, but results may not apply to all migraine patients. Rimegepant may cause side effects and is not a cure.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

Headache migraine disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MIGRAINE

Contacts and locations

Locations

  • Atago Hospital

    Kochi, Kochi, 780-0051, Japan

  • Atsuchi Neurosurgery Hospital

    Kagoshima, Kagoshima-ken, 892-0842, Japan

  • Doi Clinic Internal Medicine/Neurology

    Hiroshima, Hiroshima, 730-0031, Japan

  • Dokkyo Medical Univ. Hosp.

    Shimotsuga-gun, Tochigi, 321-0293, Japan

  • Fujitsu Clinic

    Nakahara, Kanagawa, 211-8588, Japan

  • Fukuuchi Pain Clinic

    Shinjuku-ku, Tokyo, 160-0017, Japan

  • Higashi Sapporo Neurology and Neurosurgery Clinic

    Sapporo, Hokkaido, 003-0003, Japan

  • Ikeda Neurosurgical Clinic

    Kasuga-shi, Fukuoka, 816-0824, Japan

  • Iwate Medical University Uchimaru Medical Center

    Morioka, Iwate, 020-8505, Japan

  • Japanese Red Cross Asahikawa Hospital

    Asahikawa-shi, Hokkaido, 070-8530, Japan

  • Japanese Red Cross Shizuoka Hospital

    Shizuoka, Shizuoka, 420-0853, Japan

  • Jinnouchi Neurosurgical Clinic

    Kasuga-shi, Fukuoka, 816-0802, Japan

  • Juntendo University Hospital

    Bunkyo-ku, Tokyo, 113-8431, Japan

  • Keio University Hospital

    Shinjuku-ku, Tokyo, 160-8582, Japan

  • Kijima Neurosurgery Clinic

    Kahoku-gun, Ishikawa-ken, 929-0342, Japan

  • Kindai University Hospital

    Osakasayama-shi, Osaka, 589-8511, Japan

  • Kitasato University Kitasato Institute Hospital

    Minato-ku, Tokyo, 108-8642, Japan

  • Konan Medical Center

    Higashinada-ku, Hyōgo, 658-0064, Japan

  • Makabe Clinic

    Okayama, Okayama-ken, 700-0964, Japan

  • Medical Corporation Seikokai Takanoko Hospital

    Matsuyama, Ehime, 790-0925, Japan

  • Medical Research Institute KITANO HOSPITAL, PIIF Tazuke-kofukai

    Osaka, Osaka, 530-8480, Japan

  • Mito Kyodo General Hospital

    Mito, Ibaraki, 310-0015, Japan

  • Nagamitsu Clinic

    Hofu-shi, Yamaguchi, 747-0802, Japan

  • Nagaseki Headache Clinic

    Kai-shi, Yamanashi, 400-0124, Japan

  • Nakamura Memorial Hospital

    Chūōku, Hokkaido, 060-8570, Japan

  • Nishinomiya Munic. Ctr. Hosp.

    Nishinomiya-shi, Hyōgo, 663-8014, Japan

  • Nishiogi Pain Clinic

    Suginami-ku, Tokyo, 167-0054, Japan

  • Okayama City General Medical Center Okayama City Hospital

    Okayama, Okayama-ken, 700-8557, Japan

  • Ooba Clinic for Neurosurgery & Headache

    Ōita, Oita Prefecture, 870-0831, Japan

  • SUBARU Health Insurance Society Ota Memorial Hospital

    Ota-shi, Gunma, 373-8585, Japan

  • Saiseikai Kumamoto Hospital

    Kumamoto, Kumamoto, 861- 4193, Japan

  • Saitama Medical University Hospital

    Iruma-gun, Saitama, 350-0495, Japan

  • Saitama Neuropsychiatric Institute

    Saitama-shi, Saitama, 338-8577, Japan

  • Sakura Neuro Clinic

    Toyama, Toyama, 930-0803, Japan

  • Sendai Headache and Neurology Clinic, Medical Corporation

    Sendai, Miyagi, 982-0014, Japan

  • Shinagawa Strings Clinic

    Minato-ku, Tokyo, 108-0075, Japan

  • St. Marianna Univ. Hospital

    Kawasaki-shi, Kanagawa, 216-8511, Japan

  • Takase Intern. Med. Clinic

    Toyonaka-shi, Osaka, 560-0012, Japan

  • Tanaka Neurosurgical Clinic

    Kagoshima, Kagoshima-ken, 892-0844, Japan

  • Tatsuoka Neurology Clinic

    Kyoto, Kyoto, 600-8811, Japan

  • Tokai univ. hachioji hosp.

    Hachioji-shi, Tokyo, 192-0032, Japan

  • Tominaga Clinic

    Osaka, Osaka, 556-0015, Japan

  • USUDA CLINIC for internal medicine

    Setagaya-ku, Tokyo, 156-0043, Japan

  • Umenotsuji Clinic

    Kochi, Kochi, 780-8011, Japan