Could a migraine drug stop cluster headaches? small study hints at hope
NCT ID NCT05264714
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This pilot study tested whether rimegepant (Nurtec ODT), a drug already used for migraines, could help prevent cluster headaches. Twenty adults with recurrent cluster headaches took the drug every other day for a week. Researchers measured changes in weekly attack frequency and pain severity to see if it might be a useful preventive option.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Rimegepant (Nurtec ODT)
- What this could lead to
- If it works, this could point toward a new preventive treatment for cluster headaches, reducing attack frequency.
- What could go wrong
- This is a very small pilot study with only 20 people, so results may not apply to everyone. It's early-stage and may not show clear benefit.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Mayo Clinic Rochester
Rochester, Minnesota, 55905, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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