Blood protein may help ER spot serious headaches
NCT ID NCT02683304
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study looked at whether measuring a protein called S100B in the blood can help emergency doctors tell the difference between primary headaches (like migraines) and secondary headaches (caused by something serious like a bleed or infection). Researchers enrolled 81 adults with non-traumatic headaches and compared their S100B levels, MRI results, and final diagnoses. If S100B proves reliable, it could become a quick screening tool in the ER.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- S100B protein measurement
- What this could lead to
- If S100B levels reliably distinguish dangerous secondary headaches from common ones, it could give ER doctors a quick blood test to guide care.
- What could go wrong
- This is a small pilot study (81 people) with no control group. The test may not be accurate enough, and results need confirmation in larger trials.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
CHRU de Nîmes - Hôpital Universitaire Carémeau
Nîmes, 30029, France
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