HEADACHE

This study tests whether adding a daily pill (amitriptyline) to online cognitive behavioral therapy (CBT) helps prevent migraines in children better than online therapy alone. About 400 kids with frequent migraines will be followed for months to see if headache days drop by half …

This study looks at whether the position of a neck muscle before dry needling changes how well the treatment works for chronic neck pain. About 80 adults with neck pain lasting over 3 months will be randomly assigned to have the muscle stretched or shortened during two needling s…

This study is testing whether open-label placebo pills—capsules with no active ingredients that patients know are fake—can reduce chronic pain and improve sleep in people with temporomandibular disorder (TMD). About 111 participants will be split into three groups: one gets the p…

This study is testing a nurse-led mind-body program to help children and teens with migraine have fewer headache days. The program combines different treatment parts, like relaxation and coping skills, to find the best mix. The study will include 260 participants aged 10-17 who h…

This pilot study from Mayo Clinic tests whether a virtual lifestyle behavior training program can help people with chronic migraine have fewer attacks. Sixty adults with chronic migraine for at least one year will be randomly assigned to either the lifestyle program or a sham edu…

This study tests whether a numbing nasal spray can safely reduce severe headaches after a brain aneurysm bleed. About 20 adults in the ICU will receive the spray along with standard pain meds. Researchers will compare pain levels and opioid use before and after treatment to see i…

This study tests whether osteopathic manipulative treatment (OMT) — a gentle, hands-on therapy — can reduce muscle stiffness, improve jaw motion, and ease pain in people with chronic neck pain and headaches. Thirty adults aged 19 to 65 will receive OMT and undergo various measure…

This study tests whether inserting a tiny needle into the ear and applying a mild electrical current (called percutaneous needle electrolysis) can help people with frequent headaches. Researchers will use an infrared camera to measure changes in facial skin temperature, since peo…

This study looks at whether a supervised aerobic exercise program, combined with a single session of pain education, can reduce migraine-related disability and improve sensory and muscle function. One hundred women with migraine will either exercise on a treadmill three times a w…

This study tests whether a machine learning algorithm can predict the best way to deliver repetitive transcranial magnetic stimulation (rTMS) to reduce headaches and body pain in veterans with Gulf War Illness. 140 veterans will receive 13 active rTMS sessions over 3-4 months, an…

This study tests a non-invasive device that gently stimulates a nerve in the ear to see if it can prevent headaches after a brain aneurysm procedure. About 440 adults will either get the real stimulation or a fake version. The goal is to find a safe, drug-free way to reduce pain …

This study tests a personalized, noninvasive brain stimulation technique called TMS for people aged 18–65 with chronic symptoms after a mild concussion or traumatic brain injury. Symptoms like headache, dizziness, brain fog, and anxiety can last for months. Participants will rece…

This study looks at whether surgical masks or N95 masks work better to reduce physical symptoms like headache, fatigue, and muscle pain caused by surgical smoke in operating room nurses. 38 nurses wore each type of mask for four weeks and reported their symptoms. The results show…

This study tests if delivering lidocaine (a numbing medicine) and steroids directly into an artery in the scalp can safely relieve the intense headaches that follow a type of brain bleed called subarachnoid hemorrhage. The goal is to reduce pain and the need for strong opioid pai…

This study tests a nerve block (sphenopalatine ganglion block) given through the nose to treat severe headaches after a type of brain bleed called subarachnoid hemorrhage. About 40 adults with a secured aneurysm will receive either the block plus standard pain meds or standard me…

This study tests whether a nerve block injection near the cheek can relieve severe headaches after a brain bleed (subarachnoid hemorrhage). The injection contains a numbing medicine and a steroid. The goal is to see if it reduces the need for opioid painkillers. About 195 adults …

This pilot study tests a new program called CRISP to help young adults aged 18-29 recover from concussion and manage headaches. The program focuses on support and recovery strategies. Researchers will measure how acceptable the treatment is and track changes in headache severity …

This study tests whether repetitive transcranial magnetic stimulation (rTMS), a non-invasive brain stimulation technique, can reduce chronic headaches and improve recovery in people with mild traumatic brain injury. Researchers will compare active rTMS to a sham (fake) treatment …

This online registry is studying the safety and effectiveness of the CEFALY device, a non-invasive nerve stimulator worn on the forehead, for treating migraines during and after pregnancy. Pregnant women aged 18-44 with migraines can join, regardless of whether they use the devic…

This study aims to find out which patient factors influence how well a nerve block works for medication-overuse headache. Researchers will give 70 adults an ultrasound-guided injection and track their pain and medication use for one month. The goal is to better predict who will b…

This study aims to create a large database and sample bank to better understand headaches. Researchers will collect health information and treatment records from 50,000 people with headaches. The goal is to develop a system that helps doctors diagnose and treat headaches more pre…