HEADACHE

This study tests whether adding a daily pill (amitriptyline) to cognitive behavioral therapy (CBT) delivered via video is better than CBT alone for preventing migraines in children aged 7-17. Researchers will track headache days and disability over time. The goal is to find the m…

This study looks at whether a 16-week supervised aerobic exercise program, combined with a single session of pain education, can help women aged 18 to 48 who have migraines. Participants will be randomly assigned to either the exercise group or a control group that gets advice on…

This pilot study tests a new program called CRISP to help young adults aged 18-29 recover from concussion and mild traumatic brain injury. Participants must have had a concussion at least 2 weeks ago but less than 2 years ago, with new or worsening headaches. The study will see i…

This study tests a personalized, noninvasive brain stimulation treatment (TMS) for people aged 18-65 with persistent symptoms after a mild concussion or brain injury, such as headache, dizziness, brain fog, or anxiety. Participants will receive either active or sham TMS over 10 s…

This study tests whether a numbing injection through the nose (sphenopalatine ganglion block) can better control severe headaches in people with a brain bleed (subarachnoid hemorrhage). About 40 adults with a secured aneurysm will receive either standard pain meds alone or standa…

This study tests whether a lifestyle behavior program can help people with chronic migraine have fewer and less severe headaches. Researchers will also look for biological markers linked to improvement. The goal is to see if this approach is practical and liked by participants, w…

This study tests whether a non-invasive brain stimulation technique called repetitive transcranial magnetic stimulation (rTMS) can reduce chronic headaches in people who had a mild traumatic brain injury. Researchers will track headache changes, sleep, and daily function in 60 ad…

This study tests a non-invasive device that gently stimulates a nerve in the ear to see if it can prevent or reduce headaches after a brain aneurysm repair procedure. About 440 adults who are scheduled for stent-assisted coiling will wear the device for 30 minutes twice a day, st…

This study looked at 38 operating room nurses to see if wearing a surgical mask or an N95 mask made a difference in physical symptoms caused by surgical smoke, such as headaches, dizziness, and fatigue. Nurses wore each type of mask for four weeks, and their symptoms were tracked…

This study tests a nurse-led mind-body program to help children with migraines have fewer headache days. It will enroll 260 kids aged 10-17 who have migraines with or without aura. The program combines different amounts of three treatment parts to find the best approach for reduc…

This study tests whether delivering lidocaine (a numbing medicine) and steroids directly into an artery in the brain can relieve the intense headaches that follow a type of stroke called subarachnoid hemorrhage. About 15 adults with mild-to-moderate bleeds will receive the infusi…

This study tests whether a machine learning algorithm can help personalize brain stimulation (rTMS) to better treat headaches and body pain in veterans with Gulf War Illness. About 140 veterans or active military personnel will receive 13 active rTMS sessions over 3-4 months. The…

This study tests whether a numbing injection in the face can reduce severe headaches and the need for strong painkillers after a brain bleed. About 195 adults who had a brain bleed will receive either the active injection or a placebo. The goal is to see if this approach safely c…

This study is looking at what factors in a person's health history might affect how well a nerve block injection works for medication-overuse headache. Researchers will track 70 adults who get the injection and see how their headache days and pain levels change. The goal is to be…

This study is gathering information from 50,000 people with headaches to create a better system for diagnosing and treating them. Researchers will collect medical history, treatment data, and biological samples to understand different headache types. The goal is to help doctors m…