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Nerve block may ease headaches after brain bleeding, reduce opioid use

NCT ID NCT06621329

Recruiting now Symptom relief Sponsor: University of California, Davis Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests a nerve block (sphenopalatine ganglion block) given through the nose to treat severe headaches after a type of brain bleed called subarachnoid hemorrhage. About 40 adults with a secured aneurysm will receive either the block plus standard pain meds or standard meds alone. The goal is to see if the block lowers pain scores and reduces the need for opioids during the hospital stay.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
bupivacaine with or without dexamethasone
What this could lead to
If it works, this could offer a new way to manage severe headaches after brain bleeding and reduce reliance on opioids.
What could go wrong
This is a small early-phase pilot study with only 40 people. The nerve block may not provide better pain relief than standard care, and there are risks from the procedure or medications.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Headache headache disorder subarachnoid hemorrhage

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HEADACHE SAH (SUBARACHNOID HEMORRHAGE)

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • UC Davis Medical Center

    RECRUITING

    Sacramento, California, 95817, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

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