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Can a quick neck adjustment change deep headache muscles?

NCT ID NCT07725198

Knowledge-focused Sponsor: Florida Gulf Coast University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 24, 2026 · Last updated Aug 28, 2026 · Updated 3 times

Summary

This trial tests whether two types of upper neck therapy — a quick thrust or a gentle hold — can immediately change the size and shape of a tiny neck muscle linked to headaches. Researchers will use ultrasound to measure the muscle in 80 adults with head or neck pain. The goal is to see which technique produces a faster neuromuscular response.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
upper cervical manual therapy (thrust manipulation or mobilization)
What this could lead to
If successful, this could help identify which neck therapy technique better targets muscles involved in headaches, potentially improving treatment approaches.
What could go wrong
This is a small, early-stage study measuring immediate muscle changes, not long-term outcomes. Results may not translate to lasting headache relief.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 80 people

The number the study aims to enrol. It can still change while the study runs.

Started

May 2025

Expected to finish

Jan 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 65 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * read and understand English * no previous history of cervical spine surgery or traumatic cervical injury * no contraindications to cervical manual therapy Exclusion Criteria: * any absolute contraindications to cervical manipulation * any other medical condition considered unsafe for manual therapy.

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Conditions

The condition(s) this trial relates to.

Headache headache disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Head and neck Headache

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Florida Gulf Coast University Marieb Hall 101

    RECRUITING

    Fort Myers, Florida, 33965, United States

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