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Could a common numbing drug ease Post-Brain bleed headaches?

NCT ID NCT06582810

Symptom relief Sponsor: University of Kansas Medical Center Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 10, 2026 · Last updated Jul 10, 2026

Summary

This study looks at whether an intravenous lidocaine infusion can safely reduce moderate to severe headache pain in people recovering from a non-traumatic subarachnoid hemorrhage (a type of brain bleed). Twenty adult participants with favorable neurological status will receive lidocaine and report their pain levels every two hours for up to seven days. The researchers also monitor for vasospasm, a common complication. The goal is to see if lidocaine provides meaningful pain relief and is safe in this setting.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
lidocaine infusion
What this could lead to
If it works, this could offer a new way to manage severe headaches after a brain bleed, potentially reducing reliance on opioids.
What could go wrong
This is a small, early observational study with only 20 participants, so results may not apply widely. Lidocaine can cause side effects like dizziness or heart issues.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 20 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jan 2025

Expected to finish

Jul 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Patients will be recruited once a diagnosis of non-traumatic subarachnoid hemorrhage has been confirmed and the patients meet the inclusion criteria for the study. The investigators will exclude incarcerated patients and pregnant women from the study, but the investigators will include patients that cannot consent themselves, as long as the patient meets the inclusion criteria, the investigators can gain consent from the patient's legal guardian/representative, and the patient can report a numeric pain score for the full length of the study (every 2 h the patient is awake for up to 7 days).

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients \> 18 years; * Have a favorable neurological status defined as Hunt and Hess score ≤ 3 (as it accounts for patient awareness); * Can communicate numeric pain scores; * Are diagnosed with non-traumatic subarachnoid hemorrhage Exclusion Criteria: * The patient is diagnosed with traumatic subarachnoid hemorrhage; * If the patient is \< 18 years of age; * If numeric pain scores could not be captured for \> 3 days of hospitalization; * If the patient had a prior aneurysm; * Chronic pain not associated with non-traumatic subarachnoid hemorrhage diagnosis; * A disability before the stroke (\> 2 on modified Rankin Scale score); * A Hunt and Hess score \> 3; * Contraindications to lidocaine (significant cardiac disease, arrhythmia, seizures, previous allergic reaction to lidocaine

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Conditions

The condition(s) this trial relates to.

Headache headache disorder Hemorrhage subarachnoid hemorrhage

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Headache Subarachnoid; hemorrhage, nontraumatic

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Ascension Via Christi St. Francis

    RECRUITING

    Wichita, Kansas, 67214, United States

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