Nerve block may ease headaches after brain bleed, reduce opioid use

NCT ID NCT06008795

Recruiting now Symptom relief Sponsor: University of Florida Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 07, 2026 · Updated 2 times

Summary

This study tests whether a nerve block injection near the cheek can relieve severe headaches after a brain bleed (subarachnoid hemorrhage). The injection contains a numbing medicine and a steroid. The goal is to see if it reduces the need for opioid painkillers. About 195 adults who recently had a brain bleed will be randomly assigned to get the real injection or a placebo (salt water). The study is double-blind, meaning neither patients nor doctors know who gets which treatment.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: ropivacaine and dexamethasone
What this could lead to: If it works, this could offer a non-opioid way to manage severe headaches after a brain bleed, reducing reliance on painkillers.
What could go wrong: This is an early phase 2 trial, so it's not yet proven. The nerve block may not work better than placebo, and there are risks like bleeding or infection from the injection.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

acquired aneurysmal subarachnoid hemorrhage Headache headache disorder subarachnoid hemorrhage

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HEADACHE SUBARACHNOID HEMORRHAGE, ANEURYSMAL

Contacts and locations

Locations

Cleveland Clinic Foundation Martin Health
RECRUITING

Stuart, Florida, 34994, United States
Creighton University Medical Center
RECRUITING

Omaha, Nebraska, 68124, United States
Emory University
RECRUITING

Atlanta, Georgia, 30322, United States
Medical College of Wisconsin
RECRUITING

Milwaukee, Wisconsin, 53226, United States
Oregon Health and Sciences University
RECRUITING

Portland, Oregon, 97239, United States
Thomas Jefferson University
NOT_YET_RECRUITING

Philadelphia, Pennsylvania, 19107, United States
University of Cincinnati
RECRUITING

Cincinnati, Ohio, 45267, United States
University of Florida
RECRUITING

Gainesville, Florida, 32610, United States
University of Maryland Baltimore
RECRUITING

Baltimore, Maryland, 21201, United States
University of Miami
RECRUITING

Miami, Florida, 33136, United States
University of North Carolina
RECRUITING

Chapel Hill, North Carolina, 27599, United States
University of Rochester Medical College
RECRUITING

Rochester, New York, 14642, United States
University of Washington
RECRUITING

Seattle, Washington, 98104, United States

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