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New nerve procedure shows promise for stubborn headaches

NCT ID NCT06764433

Symptom relief Sponsor: Ankara City Hospital Bilkent Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested a procedure called pulsed radiofrequency treatment on the greater occipital nerve at the C2 level in 25 people with cervicogenic headache who had not responded to other treatments. The goal was to see if it could reduce headache severity and frequency. The treatment was guided by ultrasound to target the nerve precisely.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
pulsed radiofrequency treatment of the greater occipital nerve
What this could lead to
If it works, this could offer a new option for people with cervicogenic headache who haven't gotten relief from standard treatments.
What could go wrong
This is a small, completed trial with only 25 participants. The results may not apply to everyone, and the procedure carries typical risks of nerve blocks like pain or infection.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

25 people

The number who actually took part.

Started

Mar 2023

Finished

Dec 2024

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 65 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Diagnosed with cervicogenic headache according to ICHD-3 criteria * Cranial and cervical spine imaging is available * Number of headache days per month 5 and/or more * Inadequate benefit from pharmacological treatments or physical therapy methods used * Volunteer patients who can understand and approve the treatment and the informed consent form and who can comply with the treatment Exclusion Criteria: * History of secondary headache other than cervicogenic headache according to ICHD-3 criteria * Cervical nerve root irritation and/or spinal stenosis symptoms and signs * Sensory deficit findings in the greater occipital nerve dermatome * Craniocervical defect or other anatomical abnormality in the target area or nearby the procedure * Local or systemic infection * Received nonpharmacological treatment within the last 3 months (physical therapy, botulinum toxin A, acupuncture, ozone, cognitive behavioral therapy, etc.) * Pregnancy or suspected pregnancy * Known allergy to local anesthetic drugs * History of malignancy * Known organic disease of the brain and spinal cord * History of cranial/cervical surgery within the last 1 year * Bleeding-clotting disorder or oral anticoagulant use * Comorbid disease that may cause headache (uncontrolled hypertension, intracranial lesion, etc.) * Compliance with treatment and treatment results diseases that may affect the evaluation (psychiatric disorder, dementia, etc.) * Those who request re-treatment due to the emergence of contralateral pain or other types of pain during the follow-up period after treatment * Those who do not accept treatment

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Conditions

The condition(s) this trial relates to.

Headache headache disorder Headache Disorders, Secondary Neck Pain Post-Traumatic Headache

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cervicogenic headache Headache Headache, cervicogenic Occipital nerve block Pulsed radiofrequency

Contacts and locations

Locations

  • Health Sciences University, Ankara Bilkent City Hospital

    Ankara, Cankaya, 06800, Turkey (Türkiye)

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