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Can Hands-On therapy or targeted exercise ease headaches from the neck?

NCT ID NCT07776093

Disease control Sponsor: Pamukkale University Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 20, 2026 · Last updated Aug 25, 2026 · Updated 3 times

Summary

This trial compares two physiotherapy approaches for cervicogenic headache, a type of headache originating from the upper neck. Participants will receive either manual therapy (joint mobilization, myofascial release, and trigger point therapy) or a multicomponent exercise program (deep neck flexor strengthening, proprioception, and balance training) over 4 weeks. The study measures changes in pain, neck muscle thickness, joint position sense, central sensitization, disability, and fear of movement. The goal is to see which approach better improves these outcomes in adults aged 18-45 with this condition.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Manual therapy (joint mobilization, myofascial release, trigger point therapy, suboccipital distraction) and a multicomponent exercise program (deep cervical flexor strengthening, proprioception, gaze stability, balance training)
What this could lead to
If successful, this could identify which therapy better improves neck muscle function, pain, and fear of movement in people with cervicogenic headache, potentially guiding more effective physiotherapy.
What could go wrong
This is a small, early-stage trial with only 32 participants, so results may not apply broadly. Both therapies are generally low-risk, but individual responses can vary.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 32 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Sep 2026

An estimate. Start dates often move.

Expected to finish

Mar 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 45 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Diagnosis of cervicogenic headache by a specialist physician, * Aged between 18 and 45 years, * Ability to read and write (literate), * Provision of signed informed consent to participate in the study. Exclusion Criteria: * History of head or neck surgery, * History of spinal surgery, * History of severe cardiac conditions or cardiac surgery that contraindicates exercise, * History of ongoing or past malignancy, * Diagnosis of psychiatric disorders, * Diagnosis of migraine, * Diagnosis of fibromyalgia, * Having received medical (except analgesics), physical therapy, or other interventions (e.g., alternative medicine, massage therapy) for cervicogenic headache within the last 6 months, * Engaging in regular exercise or attending an exercise facility within the last 6 months, * Experiencing headaches strictly associated with the menstrual period, * Investigator decision for exclusion based on ethical or clinical grounds, * Communication problems interfering with evaluation and treatment.

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Conditions

The condition(s) this trial relates to.

Post-Traumatic Headache Somatosensory Disorders

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cervicogenic headache Neck pain musculoskeletal Proprioceptive disorders

How to take part

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  1. The official record

    The full official record for this study. This one lists no contact details, but it is the first place any would appear.

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